A single dose of S-ketamine induces long-term antidepressant effects and decreases oxidative stress in adulthood rats following maternal deprivation

Developmental Neurobiology
Gislaine Z RéusJoão Quevedo

Abstract

Ketamine, an antagonist of N-methyl-d-aspartate receptors, has produced rapid antidepressant effects in patients with depression, as well as in animal models. However, the extent and duration of the antidepressant effect over longer periods of time has not been considered. This study evaluated the effects of single dose of ketamine on behavior and oxidative stress, which is related to depression, in the brains of adult rats subjected to maternal deprivation. Deprived and nondeprived Wistar rats were divided into four groups nondeprived + saline; nondeprived + S-ketamine (15 mg/kg); deprived + saline; deprived + S-ketamine (15 mg/kg). A single dose of ketamine or saline was administrated during the adult phase, and 14 days later depressive-like behavior was assessed. In addition, lipid damage, protein damage, and antioxidant enzyme activities were evaluated in the rat brain. Maternal deprivation induces a depressive-like behavior, as verified by an increase in immobility and anhedonic behavior. However, a single dose of ketamine was able to reverse these alterations, showing long-term antidepressant effects. The brains of maternally deprived rats had an increase in protein oxidative damage and lipid peroxidation, but administrat...Continue Reading

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Sep 20, 2017·Translational Psychiatry·A AhnaouW H I M Drinkenburg
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Jan 5, 2021·Pharmacological Reports : PR·Cinara Ludvig GonçalvesGislaine Zilli Réus
Mar 14, 2020·Pharmacology & Therapeutics·Andrea Carlo RossettiRaffaella Molteni
Mar 6, 2021·Experimental Brain Research·Ahmad Mohammadi-FaraniReza Rahimian
Nov 27, 2019·Molecular Neuropsychiatry·Gislaine Zilli RéusJoão Quevedo

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