A single-dose resveratrol treatment in a mouse model of amyotrophic lateral sclerosis

Journal of Medicinal Food
Chad D MarkertCarol E Milligan

Abstract

The underlying causes of denervation of the neuromuscular junction and eventual motor neuron death in amyotrophic lateral sclerosis (ALS) have not been resolved. The superoxide dismutase 1 (SOD1)(G93A) mutant mouse is a frequently used animal model of ALS. We hypothesized that resveratrol (RSV), a polyphenolic molecule that enhances mammalian NAD(+)-dependent SIRT1 deacetylases and may increase life span, would improve motor function and survival in the SOD1 mouse model via modulation of p53 acetylation. Data were collected for mean survival times, neuromuscular performance on the ROTOR-ROD™ (San Diego Instruments, San Diego, CA, USA), body weight, and p53 acetylation. Mean survival times were not statistically different (P=.23) between control and experimental (RSV-fed) groups (mean +/- SD, control [n=11] 138 +/- 6 days vs. experimental [n=10] 135 +/- 8 days). Performance was not significantly different between groups at time points corresponding to 50%, 80%, and 90% mean life span (P=.46), nor did RSV treatment attenuate body weight loss. Thus although manipulation of SIRT1 deacetylase activity has effects at the protein level in healthy aging organisms, we conclude that RSV treatment does not lead to functional improvement o...Continue Reading

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Citations

Sep 17, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Brett Langley, Anthony Sauve
May 22, 2013·Cell Research·Adrianna Z Herskovits, Leonard Guarente
Jan 15, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Renzo MancusoXavier Navarro
Jun 1, 2012·Expert Opinion on Drug Discovery·Marcie A Glicksman
Jul 4, 2012·Trends in Pharmacological Sciences·Gizem Donmez
Sep 21, 2011·Progress in Neurobiology·Feng ZhangJun Chen
Oct 10, 2013·British Journal of Pharmacology·J C Komen, D R Thorburn
Jun 19, 2012·Molecular and Cellular Neurosciences·Mauro CozzolinoMaria Teresa Carrì
Feb 11, 2014·Neuron·A Zara Herskovits, Leonard Guarente
Oct 9, 2018·Aging Cell·Adrianna Z HerskovitsLeonard P Guarente
Apr 5, 2019·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·UNKNOWN ALSUNTANGLED GROUP
Dec 13, 2016·Cellular and Molecular Neurobiology·Bor Luen Tang
Jul 30, 2020·British Journal of Pharmacology·Yvonne E KlinglLudo Van Den Bosch
Jan 6, 2021·Cell Death and Differentiation·Franziska OttensThorsten Hoppe
Apr 21, 2021·Molecular Neurobiology·Heena KhanThakur Gurjeet Singh

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Methods Mentioned

BETA
acetylation
protein assay

Software Mentioned

GraphPad
NanoDrop
MultiGuage
GraphPad Prism

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