PMID: 6108592Jan 1, 1980Paper

A single dose study of nabilone, a synthetic cannabinoid

Psychopharmacology
R M GlassM W Fischman

Abstract

The effects of single oral doses of nabilone, a synthetic cannabinoid, were studied in four anxious volunteer subjects. Each subject had two exposures to placebo and three dose levels of nabilone at 1 week intervals in a single blind balanced Latin square design after the nabilone dose range was determined by each subject's response to a test dose. The Profile of Mood States (POMS), a self-rating adjective checklist, was used as the quantitative measure of subjective effects. The subjects performed a continuous avoidance procedure. High doses (4 or 5 mg) of nabilone produced orthostatic hypotension. Small dose-related increases in heart rate also occurred. Despite the occurrence of highly significant levels of subjective sedation, there were no significant effects of nabilone on behavior maintained by the continuous avoidance procedure. Two of these subjects experienced an anti-anxiety effect from low (1 or 2 mg) nabilone doses, but there was no statistically significant effect on the mean POMS anxiety factor for the group as a whole. In a follow-up experiment, four other anxious subjects received comparatively lower doses of nabilone. In these subjects there were no important effects on blood pressure or heart rate, and also n...Continue Reading

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Citations

Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A Schurr
Aug 5, 2003·Pharmacology, Biochemistry, and Behavior·Giovanni DianaMassimo Pieri
Jul 13, 2001·Pharmacology & Therapeutics·A C Porter, C C Felder
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Aug 26, 2010·Pharmaceuticals·Marco BortolatoSimone Tambaro
Mar 15, 2006·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·David M BerlachMark A Ware
Aug 21, 2009·Human Psychopharmacology·José Alexandre CrippaPaolo Fusar-Poli
Feb 9, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Susan H FoxJonathan M Brotchie
Apr 17, 2018·Fundamental & Clinical Pharmacology·Régis BouquiéPascale Jolliet
Nov 7, 2019·Current Opinion in Psychiatry·Michael Van AmeringenJasmine Turna
Jun 12, 2021·Neuropharmacology·Gavin N PetrieMatthew N Hill

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