PMID: 7055401Feb 1, 1982Paper

A single dose tinidazole and doxycycline prophylaxis in elective surgery of colon and rectum. A prospective controlled clinical multicenter study

Annals of Surgery
K E GierckskyK O Viddal


Antimicrobial prophylaxis with agents active against aerobic and anaerobic micro-organisms leads to a significant reduction of infectious complications following colorectal surgery. A single dose (1600 mg) of tinidazole (a nitroimidazole derivate) and doxycycline (400 mg) will provide serum and tissue values well above minimum inhibitory concentration (MIC) values for more than 24 hours. To reduce the unwanted side effects and cost of prolonged antimicrobial prophylaxis, a prospective controlled clinical multicenter study comparing the effect of a single dose before operation of tinidazole and doxycycline to five days of prophylaxis before operation in 234 patients undergoing elective colorectal surgery was undertaken. Six patients given a single dose of prophylaxis before operation (n = 118) developed infectious complication (5.1%). Prolongation of prophylaxis before operation for four days after operation (n = 116) did not lead to any further reduction of infectious complications. A single dose of tinidazole and doxycycline before operation is a simple and effective prophylaxis against infectious complications following elective colorectal surgery.


Apr 17, 2003·Surgical Infections·Daniel P RaymondRobert G Sawyer
Jul 1, 1991·Diseases of the Colon and Rectum·L S JørgensenP Søgaard
Jun 12, 1998·The Australian and New Zealand Journal of Surgery·M McDonaldA Forbes
Jan 1, 1984·Scandinavian Journal of Infectious Diseases. Supplementum
Sep 1, 1991·The Journal of Hospital Infection·R G Tudor
Nov 1, 1986·American Journal of Surgery·J T DiPiroJ A Mansberger
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·H Kehlet, F Moesgaard
May 13, 2014·The Cochrane Database of Systematic Reviews·Richard L NelsonMarija Barbateskovic
Feb 10, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S G LarsenK-E Giercksky
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·T Midtvedt
Sep 1, 1984·Pharmacotherapy·T G Burnakis
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·K E GierckskyA Revhaug

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