A single dose zoledronic acid enhances pin fixation in high tibial osteotomy using the hemicallotasis technique. A double-blind placebo controlled randomized study in 46 patients

Bone
Anna Kajsa HardingAnnette W-Dahl

Abstract

Bisphosphonates have been shown to reduce osteoclastic activity and enhance pin fixation in both experimental and clinical studies. In this prospective, randomized study of high tibial osteotomy using the hemicallotasis (HCO) technique, we evaluate whether treatment by one single infusion of zoledronic acid can enhance the pin fixation. 46 consecutive patients (35-65 years) were operated on for knee osteoarthritis by the HCO technique. After the osteotomy, two hydroxyapatite-coated pins were inserted in the metaphyseal bone and two non-coated pins in the diaphyseal bone. The insertion torque was measured by a torque force screw driver. Four weeks postoperatively, the patients were randomized to either one infusion of zoledronic acid or sodium chloride intravenously. At time for removal of the pins, the extraction torque forces of the pins were measured. All osteotomies healed and no difference was found in time to healing. The mean extraction torque force in the non-coated pins in the diaphyseal bone was doubled in the zoledronic treated group (4.5 Nm, SD 2.1) compared to the placebo group (2.4 (SD 1.0, p<0.0001). The mean extraction torque forces of the hydroxyapatite-coated pins in the metaphyseal bone were similar in the zol...Continue Reading

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Citations

Jun 26, 2012·Strategies in Trauma and Limb Reconstruction·Nando Ferreira, Leonard Charles Marais
Feb 25, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Emad A AnamReggie Hamdy
Oct 1, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y-T LiZ-L Zhang
Apr 17, 2018·The Journal of International Medical Research·Lei Yang, Maowei Yang
Mar 2, 2018·Acta Orthopaedica·Geir Aasmund HjorthaugSigbjørn Dimmen

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