A single-electrode electrochemical system for multiplex electrochemiluminescence analysis based on a resistance induced potential difference

Chemical Science
Wenyue GaoGuobao Xu

Abstract

Developing low-cost and simple electrochemical systems is becoming increasingly important but still challenged for multiplex experiments. Here we report a single-electrode electrochemical system (SEES) using only one electrode not only for a single experiment but also for multiplex experiments based on a resistance induced potential difference. SEESs for a single experiment and multiplex experiments are fabricated by attaching a self-adhesive label with a hole and multiple holes onto an ITO electrode, respectively. This enables multiplex electrochemiluminescence analysis with high sensitivity at a very low safe voltage using a smartphone as a detector. For the multiplex analysis, the SEES using a single electrode is much simpler, cheaper and more user-friendly than conventional electrochemical systems and bipolar electrochemical systems using electrode arrays. Moreover, SEESs are free from the electrochemiluminescent background problem from driving electrodes in bipolar electrochemical systems. Since numerous electrodes and cover materials can be used to fabricate SEESs readily and electrochemistry is being extensively used, SEESs are very promising for broad applications, such as drug screening and high throughput analysis.

References

May 29, 2008·Journal of the American Chemical Society·Kwok-Fan ChowRichard M Crooks
Dec 22, 2011·Journal of the American Chemical Society·Stephen E Fosdick, Richard M Crooks
Oct 9, 2012·Angewandte Chemie·Milica SenticNeso Sojic
May 31, 2013·Accounts of Chemical Research·Gabriel LogetAlexander Kuhn
Jul 12, 2013·Angewandte Chemie·Stephen E FosdickRichard M Crooks
Feb 28, 2014·Angewandte Chemie·Steven E F KleijnPatrick R Unwin
Apr 8, 2014·Analytical and Bioanalytical Chemistry·Lei GeMei Yan
Jul 9, 2014·Analytical and Bioanalytical Chemistry·Paolo BertoncelloLynn Dennany
Sep 4, 2014·Analytical Chemistry·Wenjing QiGuobao Xu
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Mar 25, 2015·Chemical Society Reviews·Zhongyuan LiuGuobao Xu
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May 18, 2016·Analytical and Bioanalytical Chemistry·Laurent BouffierNeso Sojic

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Citations

Feb 8, 2020·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Laurent BouffierNeso Sojic
Mar 27, 2020·Chemical Communications : Chem Comm·Jun ChenWensheng Yang
Jul 26, 2019·Chemical Science·Miao-Miao ChenWei-Hua Huang
Feb 6, 2021·Topics in Current Chemistry·Javad TavakoliYouhong Tang
Mar 6, 2019·Analytical Chemistry·Wenyue GaoEric Bakker
May 25, 2021·Analytical Methods : Advancing Methods and Applications·Gen ChenChen Gao
Jun 25, 2021·Accounts of Chemical Research·Xiangui MaGuobao Xu
May 5, 2021·Annual Review of Analytical Chemistry·Laurent BouffierAlexander Kuhn
Nov 25, 2020·Analytical Chemistry·Kira L Rahn, Robbyn K Anand
Aug 23, 2019·The Journal of Physical Chemistry Letters·Alice L DauphinNeso Sojic

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