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A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans

Nature Genetics

Jan 29, 2008

Insuk LeeE M Marcotte

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PubMed

Abstract

The fundamental aim of genetics is to understand how an organism's phenotype is determined by its genotype, and implicit in this is predicting how changes in DNA sequence alter phenotypes. A single network covering all the genes of an organism might guide such predictions down to the le...read more

Mentioned in this Paper

Calcinus elegans
Cyartonema elegans
Coleonyx elegans
Biochemical Pathway
Tumor Suppressor Genes
DMD gene
Cestrum elegans
Clarkia unguiculata
Clathrulina elegans
Cardioglossa elegans
1
400
Paper Details
References
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  • Citations167
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  • References48
  • Citations167
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A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans

Nature Genetics

Jan 29, 2008

Insuk LeeE M Marcotte

PMID: 18223650

DOI: 10.1038/ng.2007.70

Abstract

The fundamental aim of genetics is to understand how an organism's phenotype is determined by its genotype, and implicit in this is predicting how changes in DNA sequence alter phenotypes. A single network covering all the genes of an organism might guide such predictions down to the le...read more

Mentioned in this Paper

Calcinus elegans
Cyartonema elegans
Coleonyx elegans
Biochemical Pathway
Tumor Suppressor Genes
DMD gene
Cestrum elegans
Clarkia unguiculata
Clathrulina elegans
Cardioglossa elegans
1
400

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Structural Biology: Biophysics

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Paper Details
References
  • References48
  • Citations167
12345
  • References48
  • Citations167
12345...

Download from

Publisher
PubMed
/papers/a-single-gene-network-accurately-predicts/18223650