A single institutional experience with definitive radiotherapy for cervical cancer using both high- and low-dose-rate brachytherapy

Gynecologic Oncology
Kristina GersztenClare Faul

Abstract

To evaluate outcomes in cervical cancer patients treated with high-dose-rate (HDRB) or low-dose-rate (LDRB) brachytherapy. A retrospective chart review compared control rates, survival, and complications in the two groups. All patients received pelvic EBRT (45 Gy/5 weeks). 106 patients receiving LDRB were compared to 107 treated with HDRB. The median point A LDRB and HDRB dose was 42 Gy and 25 Gy/5, respectively. Tumor size and stage (I(B) 23% LDRB, 30% HDRB, II(A) 22% LDRB, 11% HDRB, II(B) 44% LDRB, 48% HDRB, III(B) 11% LDRB and HDRB) were similar, but more HDRB patients received chemosensitization (44% versus 6%). After adjusting for lymph node status with cox regression, no difference in 5-year survival (53% HDRB and 61% LDRB P = 0.088) or 5-year DFS (54% both groups, P = 0.089) was found between the two groups. Local recurrences occurred in 19% of the LDRB and 5% of the HDRB cohort. The time to LR was significantly longer in the HDRB group, and this persisted after adjusting for the increased used of chemotherapy in these patients. There was no significant difference in grade III or IV toxicity (6.6% LDRB and 3.7% HDRB). This HDRB dose fractionation schedule yielded improved local control but similar survival compared to LDRB.

References

Sep 1, 1990·International Journal of Radiation Oncology, Biology, Physics·K K Fu, T L Phillips
Jan 15, 1994·International Journal of Radiation Oncology, Biology, Physics·F D PatelB D Gupta
Jun 14, 2002·International Journal of Radiation Oncology, Biology, Physics·Brij M SoodBhadrasain Vikram
Jul 23, 2003·International Journal of Radiation Oncology, Biology, Physics·Takafumi ToitaSadayuki Murayama

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Citations

Sep 19, 2012·Current Oncology Reports·Azmat H Sadozye, Nicholas Reed

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