PMID: 7544398Sep 1, 1995Paper

A single nine-amino acid peptide induces virus-specific, CD8+ human cytotoxic T lymphocyte clones of heterogeneous serotype specificities

The Journal of Experimental Medicine
J ZivnyF A Ennis

Abstract

It is generally accepted that virus-specific CD8+ cytotoxic T lymphocytes (CTLs) recognize nine-amino acid peptides in conjunction with HLA class I molecules. We recently reported that dengue virus-specific CD8+ CTLs of two different serotype specificities, which were established by stimulation with dengue virus, recognize a single nine-amino acid peptide of the nonstructural protein NS3 of dengue virus type 4 (D4V) in an HLA-B35-restricted fashion. To further analyze the relationships between the serotype specificities of T cells and the amino acid sequence of the recognized peptides, we examined the ability of this viral peptide D4.NS3.500-508 (TPEGIIPTL) to stimulate T lymphocytes of an HLA-B35-positive, dengue virus type 4-immune donor. Peptide stimulation of the PBMC generated dengue virus-specific, HLA-B-35-restricted CD8+ CTL clones. These clones lysed dengue virus-infected autologous cells, as well as autologous target cells pulsed with this peptide. Four patterns of dengue virus serotype specificities were demonstrated on target cells infected with dengue-vaccinia recombinant viruses or pulsed with synthetic peptides corresponding to amino acid sequences of four dengue virus serotypes. Two serotype-specific clones reco...Continue Reading

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Citations

Dec 1, 1996·Vaccine·P J Kuebler, D F Nixon
Sep 19, 1998·Clinical and Diagnostic Virology·M A BrintonF A Ennis
Jul 30, 2010·Journal of Virology·Jason BottenMichael J Buchmeier
Jan 1, 2010·Annual Review of Chemical and Biomolecular Engineering·Michael W Deem, Pooya Hejazi
Oct 17, 2013·PLoS Neglected Tropical Diseases·Eduardo J M NascimentoErnesto T A Marques
Feb 9, 2010·Comparative Immunology, Microbiology and Infectious Diseases·Yang Xiao-mengFang Dan-yun
Jun 15, 2007·European Journal of Immunology·Whitney E PurthaMichael S Diamond
Oct 8, 2008·Immunological Reviews·Anuja Mathew, Alan L Rothman
Apr 2, 2004·The Journal of Clinical Investigation·Alan L Rothman
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adrianus C M BoonGuus F Rimmelzwaan
Sep 26, 2019·Frontiers in Immunology·Yuan TianDaniela Weiskopf
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·W KuonJ Sieper
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iva ZivnaAlan L Rothman

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