A single nucleotide polymorphism of macrophage migration inhibitory factor is related to inflammatory response in coronary bypass surgery using cardiopulmonary bypass

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Lutz E LehmannFrank Stüber

Abstract

Cardiac surgery causes induction and release of inflammatory mediators that may be regulated by genetic background. Macrophage migration inhibitory factor (MIF) is a proinflammatory mediator that is known to be up-regulated in patients undergoing cardiac operations. Here we analyzed genotype distribution and allele frequency of the MIF-173*G/C single nucleotide polymorphism (SNP) and MIF plasma levels in patients undergoing surgical revascularization with (on-pump, n=45) and without (off-pump, n=34) cardiopulmonary bypass (CPB). Genotyping was performed using a real-time PCR-based system with a hybridization probe system specific for the MIF-173*G/C SNP. In on-pump patients, blood samples were drawn before start of CPB, after termination of CPB and 12h postoperatively. In off-pump patients, blood samples were collected before stabilizer placement, after removal of the stabilizer and 12h postoperatively. MIF levels were measured using ELISA technique. Genotype distribution and allele frequencies were comparable between on-pump and off-pump patients. When comparing patients according to MIF genotype, a significant increase of MIF plasma levels after completed coronary bypass grafting using CPB was found in patients heterozygous f...Continue Reading

Citations

Aug 12, 2014·Journal of Immunology Research·Emmanuel Valdés-AlvaradoJorgé Ramón Padilla-Gutiérrez
Oct 24, 2007·British Journal of Pharmacology·M-S SuleimanG D Angelini
Jun 1, 2017·Expert Opinion on Therapeutic Targets·Pathricia V TilstamRichard Bucala
Dec 22, 2007·Cell Biochemistry and Function·C Selim IsbirSinan Arsan
Jun 1, 2011·American Journal of Reproductive Immunology : AJRI·Chao LiZi-Jiang Chen
Jul 25, 2014·Annals of the Rheumatic Diseases·T H C M ReinardsM W Schilham

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