Abstract
The AndesOrthohantavirus (ANDV), which causes the hantavirus cardiopulmonary syndrome, enters cells via integrins, and a change from leucine to proline at residue 33 in the PSI domain (L33P), impairs ANDV recognition. We assessed the association between this human polymorphism and ANDV infection. We defined susceptible and protective genotypes as "TT" (coding leucine) and "CC" (coding proline), respectively. TT was present at a rate of 89.2% (66/74) among the first cohort of ANDV cases and at 60% (63/105) among exposed close-household contacts, who remained uninfected (p < 0.05). The protective genotype (CC) was absent in all 85 ANDV cases, in both cohorts, and was present at 11.4% of the exposed close-household contacts who remained uninfected. Logistic regression modeling for risk of infection had an OR of 6.2⁻12.6 (p < 0.05) in the presence of TT and well-known ANDV risk activities. Moreover, an OR of 7.3 was obtained when the TT condition was analyzed for two groups exposed to the same environmental risk. Host genetic background was found to have an important role in ANDV infection susceptibility, in the studied population.
References
Apr 1, 1997·Emerging Infectious Diseases·C Schmaljohn, B Hjelle
Sep 30, 1998·Gastroenterology·J F MiquelF Nervi
Dec 29, 1998·Emerging Infectious Diseases·J ToroT G Ksiazek
Apr 10, 1999·Journal of Virology·I N GavrilovskayaE R Mackow
Feb 12, 2000·Journal of Medical Microbiology·P J PadulaE L Segura
Aug 31, 2000·The Journal of Biological Chemistry·E BorgesE Ruoslahti
Oct 12, 2002·Archives of Virology·I N GavrilovskayaE R Mackow
Jan 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tracy RaymondErich R Mackow
Sep 13, 2006·Emerging Infectious Diseases·Pablo A VialMarcela Ferrés
May 2, 2007·The Journal of Infectious Diseases·Marcela FerresUNKNOWN Andes Virus Household Contacts Study Group
Feb 29, 2008·Journal of Virology·Ellen Krautkrämer, Martin Zeier
Mar 28, 2008·Journal of Virology·Irina N GavrilovskayaErich R Mackow
Apr 19, 2008·Viral Immunology·Zhengwen LiuNi Zhang
Jan 1, 2009·Journal of Virology·Rafael A MedinaBrian Hjelle
Mar 17, 2009·Human Immunology·Zhengwen LiuJie Fang
Oct 23, 2009·Journal of Virology·Valery S MatthysErich R Mackow
Feb 9, 2012·Nature Reviews. Genetics·Stephen J Chapman, Adrian V S Hill
Mar 16, 2013·Journal of Viral Hepatitis·J AnguloM López-Lastra
Sep 11, 2013·Nature Reviews. Microbiology·Antti VaheriJukka Mustonen
Feb 26, 2014·Emerging Infectious Diseases·Jonathan J NúñezUNKNOWN Yosemite Hantavirus Outbreak Investigation Team
Jun 4, 2014·The Journal of Experimental Medicine·Martin J RafteryGünther Schönrich
Oct 2, 2014·Emerging Infectious Diseases·Constanza Martinez-ValdebenitoMarcela Ferrés
Mar 18, 2015·Nature Communications·Susana EyheramendyGabriela M Repetto
Oct 29, 2015·Diagnostic Microbiology and Infectious Disease·Cecilia VialFrancisca Valdivieso
Feb 13, 2017·Virologica Sinica·Xiao-Ping ChenWei Hou
Nov 23, 2018·Nature·Rohit K JangraKartik Chandran