A single oral dose of Silodosin and Diclofenac sodium is effective in reducing pain after ureteric stent removal: a prospective, randomized, double blind placebo-controlled study

SpringerPlus
Goto GangkakSatinder Pal Aggarwal

Abstract

A prospective double-blinded placebo controlled randomized study was conducted in our institute to compare the efficacy of oral Silodosin, an alpha 1 selective antagonist and Diclofenac in relieving pain after stent removal. All patients with unilateral stent placement following renal and ureteric stone endoscopic surgery were randomized into four groups: group A (Placebo), group B (Diclofenac), group C (Silodosin) and group D (combination of Diclofenac and Silodosin). Visual analogue score (VAS score) and other relevant parameters were assessed during OPD visit. Patients were handed over randomized drug envelope and asked to take the medications one hour before the stent removal. Patients were contacted 24 h after stent removal and relevant parameters were recorded. The mean VAS scores were significantly decreased in Diclofenac (2.9), Silodosin (3.08) and combination group (2.85) when compared to placebo (4.20) (p < 0.001). However there was no statistically significant difference in VAS scores between the treatment groups, i.e., group B, C and D (p > 0.5). Analgesics requirement and severe pain rates were not significantly reduced (p = 0.07, 0.35) in the three treatment groups when compared to placebo. Thus Silodosin and Dicl...Continue Reading

References

Jan 1, 1989·Biopharmaceutics & Drug Disposition·S S ChuaE J Triggs
Jan 1, 1988·The Journal of Urology·S G Pollard, R Macfarlane
Oct 7, 1997·Clinical Pharmacokinetics·N M Davies, K E Anderson
Nov 8, 2001·Journal of Endourology·A RaneR Tiptaft
Feb 11, 2003·The Journal of Urology·H B JoshiMichael J Barry
Jan 18, 2006·Urology·Charalambos DeliveliotisIoannis M Varkarakis
Feb 9, 2006·British Journal of Pharmacology·Martin C Michel, Wim Vrydag
Mar 11, 2006·Drugs·Marleen M van DijkMartin C Michel
Aug 8, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Yasunori ItohKenjiro Kohri
Mar 15, 2008·Journal of Endourology·Rocco DamianoMassimo D'Armiento
Nov 18, 2008·The Journal of Urology·Richard BeddingfieldManoj Monga
Aug 21, 2010·The Journal of Urology·Athanasios DellisFrancis X Keeley

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Citations

Mar 21, 2021·European Urology Focus·Jong Keun KimUNKNOWN Young Endourological Study group

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