A single pair of neurons modulates egg-laying decisions in Drosophila

PloS One
Chia-Lin WuSheng-Rong Yeh

Abstract

Animals have to judge environmental cues and choose the most suitable option for them from many different options. Female fruit flies selecting an optimum site to deposit their eggs is a biologically important reproductive behavior. When given the direct choice between ovipositing their eggs in a sucrose-containing medium or a caffeine-containing medium, female flies prefer the latter. However, the neural circuits and molecules that regulate this decision-making processes during egg-laying site selection remain poorly understood. In the present study, we found that amnesiac (amn) mutant flies show significant defects in egg-laying decisions, and such defects can be reversed by expressing the wild-type amn transgene in two dorsal paired medial (DPM) neurons in the brain. Silencing neuronal activity with an inward rectifier potassium channel (Kir2.1) in DPM neurons also impairs egg-laying decisions. Finally, the activity in mushroom body αβ neurons is required for the egg-laying behavior, suggesting a possible "DPM-αβ neurons" brain circuit modulating egg-laying decisions. Our results highlight the brain circuits and molecular mechanisms of egg-laying decisions in Drosophila.

References

Jan 18, 1979·Nature·W G QuinnR Booker
Jan 1, 1996·Journal of Physiology, Paris·T TullyK Velinzon
Apr 3, 2003·Nature Reviews. Neuroscience·Martin Heisenberg
Dec 9, 2003·Neuron·Takuya TamuraMinoru Saitoe
Jun 9, 2006·Nature·William J JoinerAmita Sehgal
Jun 3, 2008·Biochemical and Biophysical Research Communications·Weijie LiuAike Guo
Oct 30, 2008·Neuron·Xiao-Jing Wang
Nov 18, 2008·Journal of Neurogenetics·Chia-Lin Wu, Ann-Shyn Chiang
Jan 14, 2009·Journal of Neurogenetics·Yoshinori AsoHiromu Tanimoto
Aug 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Pei-Tseng LeeAnn-Shyn Chiang
Jul 24, 2012·Neuropharmacology·Ana M SebastiãoJoaquim A Ribeiro
Feb 23, 2013·Science·Balint Z KacsohTodd A Schlenke
Dec 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Reza AzanchiUlrike Heberlein

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Citations

May 16, 2017·Nature Communications·Wei-Huan ShyuChia-Lin Wu
Nov 29, 2017·Nature Communications·Pierre-Yves MussoThomas Preat
Jun 6, 2019·Journal of Neurogenetics·Kevin M CuryNicolas Gompel
Nov 5, 2016·Annual Review of Entomology·Liliane SchoofsMatthias Boris Van Hiel

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