PMID: 7537382Apr 25, 1995Paper

A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription

Proceedings of the National Academy of Sciences of the United States of America
J J LebrunP A Kelly

Abstract

Members of the cytokine/growth hormone/prolactin (PRL) receptor superfamily are associated with cytoplasmic tyrosine kinases of the Jak family. For the PRL receptor (PRLR), after PRL stimulation, both the kinase Jak2 and the receptor undergo tyrosine phosphorylation. To assess the role of tyrosine phosphorylation of the PRLR in signal transduction, several mutant forms of the PRLR in which various tyrosine residues were changed to phenylalanine were constructed and their functional properties were investigated. We identified a single tyrosine residue located at the C terminus of the PRLR to be necessary for in vivo activation of PRL-responsive gene transcription. This clearly indicates that a phosphotyrosine residue in the cytoplasmic domain of a member of the cytokine/growth hormone/PRL receptor superfamily is directly involved in signal transduction.

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Citations

Mar 4, 1998·Molecular and Cellular Endocrinology·R PiccolettiP Maroni
Jan 12, 2000·Molecular and Cellular Endocrinology·D Devost, J M Boutin
Jan 12, 2000·Molecular and Cellular Endocrinology·S TomicS Ali
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Jun 1, 2000·Development, Growth & Differentiation·T YamamotoA Kawahara
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Roman L BogoradUNKNOWN Benign Breast Diseases Study Group
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May 12, 2012·Endocrine Reviews·Charles L Brooks
Aug 14, 2013·Journal of Molecular Endocrinology·Guixian BuYajun Wang
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Jul 1, 1997·Molecular Endocrinology·M Perrot-ApplanatP A Kelly
Feb 29, 2000·The Journal of Biological Chemistry·A HermanJ Djiane

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