A single psilocybin dose is associated with long-term increased mindfulness, preceded by a proportional change in neocortical 5-HT2A receptor binding.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Martin K MadsenGitte M Knudsen

Abstract

A single dose of the serotonin 2A receptor (5-HT2AR) agonist psilocybin can have long-lasting beneficial effects on mood, personality, and potentially on mindfulness, but underlying mechanisms are unknown. Here, we for the first time conduct a study that assesses psilocybin effects on cerebral 5-HT2AR binding with [11C]Cimbi-36 positron emission tomography (PET) imaging and on personality and mindfulness. Ten healthy and psychedelic-naïve volunteers underwent PET neuroimaging of 5-HT2AR at baseline (BL) and one week (1W) after a single oral dose of psilocybin (0.2-0.3 mg/kg). Personality (NEO PI-R) and mindfulness (MAAS) questionnaires were completed at BL and at three-months follow-up (3M). Paired t-tests revealed statistically significant increases in personality Openness (puncorrected = 0.04, mean change [95%CI]: 4.2[0.4;∞]), which was hypothesized a priori to increase, and mindfulness (pFWER = 0.02, mean change [95%CI]: 0.5 [0.2;0.7]). Although 5-HT2AR binding at 1W versus BL was similar across individuals (puncorrected = 0.8, mean change [95%CI]: 0.007 [-0.04;0.06]), a post hoc linear regression analysis showed that change in mindfulness and 5-HT2AR correlated negatively (β [95%CI] = -5.0 [-9.0; -0.9], pFWER= 0.046). In co...Continue Reading

Citations

Nov 12, 2020·Journal of Psychopharmacology·Ari Brouwer, Robin Lester Carhart-Harris
Oct 31, 2020·Acta Psychiatrica Scandinavica·Kristoffer A A AndersenDavid Erritzoe
Jan 28, 2021·Journal of Psychopharmacology·Dea Siggaard StenbækPatrick MacDonald Fisher
Mar 6, 2021·Journal of Psychopharmacology·Tim Hirschfeld, Timo T Schmidt
Feb 23, 2021·Journal of Psychopharmacology·Albert Garcia-RomeuRoland R Griffiths
Apr 17, 2021·ACS Pharmacology & Translational Science·Jake E PaynePaul Liknaitzky
Apr 24, 2021·Social Cognitive and Affective Neuroscience·Maja Rou Marstrand-JoergensenPatrick M Fisher
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Henry LoweLorenzo Gordon
Jul 31, 2021·Frontiers in Psychology·Sascha B ThalPetra M Skeffington
Jul 14, 2021·Psychological Medicine·Isabel WießnerLuís Fernando Tófoli
Jul 12, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martin K MadsenPatrick M Fisher
Aug 8, 2021·International Journal of Molecular Sciences·Karolina E KolaczynskaMatthias E Liechti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Texas Medicine
D Mulkey
Semaine médicale professionelle et médico-sociale
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Martin K MadsenGitte M Knudsen
© 2021 Meta ULC. All rights reserved