A Single Radioactive Iodine Treatment Has a Deleterious Effect on Ovarian Reserve in Women with Thyroid Cancer: Results of a Prospective Pilot Study

Thyroid : Official Journal of the American Thyroid Association
Iris YaishKaren M Tordjman

Abstract

Women of reproductive age with differentiated thyroid cancer (DTC) often need radioactive iodine (RAI) treatment after surgery. In contrast to the well-documented effect of RAI on testicular function, the potential negative effects of this treatment on ovarian reserve have been largely dismissed. The objective of this pilot study was to examine the possibility that RAI treatment is deleterious to the ovarian reserve by prospectively measuring the concentration of anti-Müllerian hormone (AMH) after RAI treatment. Thirty premenopausal women (Mage = 34 years; range 20-45 years) with a new diagnosis of DTC scheduled to undergo RAI ablation were recruited for this study. All of them had TNM stage 1 disease (T1-3, N0, or N1, M0), and were scheduled to receive RAI activities ranging from 30 to 150 mCi. AMH was measured at baseline and at 3, 6, 9, and 12 months after the administration of RAI. Of the 30 women, only 24 returned after the baseline assessment. RAI treatment resulted in a significant decrease in AMH concentrations at three months, from 3.25 ± 2.75 to 1.9 ± 1.74 ng/mL (p < 0.0001). Only partial recovery was subsequently documented. Eighty-two percent of subjects had final values below baseline levels, such that at one year,...Continue Reading

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Citations

Aug 30, 2018·Thyroid : Official Journal of the American Thyroid Association·Berna EvranosBekir Cakir
Feb 1, 2019·Thyroid : Official Journal of the American Thyroid Association·Iris YaishKaren M Tordjman
May 9, 2019·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Angelo CagnacciAnne Gompel
Jan 7, 2020·Thyroid : Official Journal of the American Thyroid Association·Chrysoula Dosiou
Jan 14, 2020·Thyroid : Official Journal of the American Thyroid Association·Evert F S van VelsenRobin P Peeters
May 7, 2020·Thyroid : Official Journal of the American Thyroid Association·Eleonora HorvathPaulina González
Feb 23, 2020·Thyroid : Official Journal of the American Thyroid Association·Marloes NiesThera P Links
Aug 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Loes M E Moolhuijsen, Jenny A Visser
Oct 28, 2019·Thyroid : Official Journal of the American Thyroid Association·Meng RaoLi Tang
Jun 9, 2020·Journal of Cancer Survivorship : Research and Practice·Samantha A Diamond-RossiKristi D Graves
Oct 6, 2020·Thyroid : Official Journal of the American Thyroid Association·Marceline W PiekIris M C van der Ploeg

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Methods Mentioned

BETA
Cesarean section
enzyme-linked immunosorbent assay
contraception

Software Mentioned

SPSS Statistics

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