A single-season prospective study of respiratory viral infections in lung transplant recipients

The European Respiratory Journal
Aaron MilstoneStephen Dummer

Abstract

The frequency and complications of respiratory viral infections (RVI) were studied in 50 ambulatory lung transplant patients during a single winter season, using viral antigens, viral cultures and PCR of nasal washes or bronchoalveolar lavages. Patients' survival, episodes of acute rejection and occurrence of bronchiolitis obliterans (BO) or BO syndrome (BOS) were monitored for 1 yr after the study. Overall, 32 (64%) patients had 49 symptomatic episodes. Documented infections included eight due to respiratory syncytial virus (RSV), one due to parainfluenza virus (PIV) and 10 due to influenza (FLU). Four of the FLU infections were serological rises without symptoms. Overall, 17 (34%) patients had documented viral infection; four patients had lower respiratory involvement and two (one RSV, one PIV) were hospitalised for aerosolised ribavirin treatment. After 1 yr there were three (6%) deaths unrelated to RVI. BO or BOS had occurred in one (6%) out of 17 patients with and three (12%) out of 33 without RVI. Respiratory viruses infected one-third of ambulatory lung transplant recipients in a single season. In conclusion, respiratory viral infection was not associated with subsequent graft dysfunction. Larger prospective studies are ...Continue Reading

Citations

Feb 9, 2011·Der Pathologe·D TheegartenK-D Müller
Apr 1, 2010·Seminars in Respiratory and Critical Care Medicine·Pali Dedhiya Shah, John F McDyer
Nov 7, 2007·Transplantation·Francisco López-MedranoEnrique Moreno-González
Jul 29, 2008·American Journal of Respiratory and Critical Care Medicine·Peter HopkinsMichael Nissen
Sep 21, 2010·American Journal of Respiratory and Critical Care Medicine·Martin R ZamoraAllan R Glanville
May 25, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lily LiLara Danziger-Isakov
Nov 14, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cynthia E FisherAjit P Limaye
Apr 23, 2011·Clinics in Chest Medicine·Karen D Sims, Emily A Blumberg
Mar 23, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Shahid HusainUNKNOWN ISHLT Infectious Diseases Council Working Group on Definitions
Mar 1, 2011·Revue de pneumologie clinique·C KnoopM Estenne
May 15, 2010·Infectious Disease Clinics of North America·Deepali Kumar, Atul Humar
Apr 21, 2010·Revue des maladies respiratoires·C KnoopM Estenne
Oct 20, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ilker UçkayChristian van Delden
Mar 24, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ilka EngelmannJens Gottlieb
Jul 24, 2007·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·Kerry C Willis
Sep 13, 2008·Pediatric Transplantation·Marian G MichaelsPablo J Sánchez
May 9, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M LiuL A Danziger-Isakov
Nov 19, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E J Ariza-HerediaL Abbo
Jun 2, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D HayesA B Phillips
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·O ManuelUNKNOWN AST Infectious Diseases Community of Practice
Dec 16, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·I EngelmannF Mattner
Dec 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S S WeigtJ A Belperio
Apr 28, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D-L VuL Kaiser
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M G IsonUNKNOWN AST Infectious Diseases Community of Practice
Mar 11, 2010·Pediatric Transplantation·M LiuL A Danziger-Isakov
Jun 13, 2015·Current Infectious Disease Reports·Kari Neemann, Alison Freifeld
Jan 16, 2008·Orvosi hetilap·Krisztina CzebeEszter Csiszér
Dec 4, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Carl M PreiksaitisAjit P Limaye
Apr 21, 2017·Expert Opinion on Pharmacotherapy·Shellee A GrimNina M Clark
Mar 8, 2012·The Annals of Pharmacotherapy·Lauren M Hynicka, Christopher R Ensor
Apr 17, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kak-Ming LingAnthony Kicic
Apr 3, 2019·Current Opinion in Organ Transplantation·Jens Gottlieb
May 19, 2010·Expert Review of Respiratory Medicine·Isabel P NeuringerRobert M Aris
Jun 20, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stuart C SweetLara Danziger-Isakov
Jul 24, 2012·Current Opinion in Critical Care·Thomas FuehnerJens Gottlieb
Jun 29, 2013·Current Opinion in Infectious Diseases·Sarah Shalhoub, Shahid Husain
Sep 12, 2019·BMJ : British Medical Journal·Hannah H Nam, Michael G Ison
Oct 25, 2016·Transplantation·Paul R AllynAric L Gregson
May 16, 2019·Current Opinion in Organ Transplantation·Jens Gottlieb
Jan 1, 2012·Current Respiratory Care Reports·Katherine M Vandervest, Martin R Zamora

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