A single treatment of yttrium-90-labeled CHX-A"-C6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice

Cancer Research
Gregory P AdamsLouis M Weiner

Abstract

Antitumor diabody molecules are noncovalent single-chain Fv dimers that recapitulate the divalent binding properties of native IgG antibodies. Diabodies are capable of substantial accumulation in tumor xenografts expressing relevant antigens in immunodeficient mouse models. With a Mr of approximately 55,000, diabodies are rapidly cleared from the circulation, resulting in tumor-to-blood ratios that significantly exceed those achieved early after the administration of monoclonal antibodies. We have evaluated the therapeutic potential of the beta-emitting isotope yttrium-90 (t1/2, 64 hours) conjugated to the C6.5K-A diabody that specifically targets the HER2/neu human tumor-associated antigen. We have found that a single intravenous dose of 150 microCi (200 microg) 90Y-CHX-A"-C6.5K-A diabody substantially inhibits the growth rates of established MDA-361/DYT2 human breast tumor xenografts in athymic nude mice. In contrast, 300 microCi (300 microg) 90Y-CHX-A"-C6.5K-A diabody resulted in only a minor delay in the growth of SK-OV-3 human ovarian cancer xenografts. The maximum tolerated dose was also dependent on the tumor xenograft model used. These studies indicate that genetically engineered antitumor diabody molecules can be used ...Continue Reading

References

Apr 19, 1989·Journal of the National Cancer Institute·R K Jain
Aug 12, 1993·The New England Journal of Medicine·M S KaminskiG M Butchko
Oct 21, 1993·The New England Journal of Medicine·O W PressB Porter
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P HolligerG Winter
Feb 1, 1996·Immunotechnology : an International Journal of Immunological Engineering·A M WuJ E Shively
May 1, 1995·Immunotechnology : an International Journal of Immunological Engineering·R SchierL M Weiner
Mar 31, 2000·Nature Medicine·R A ClynesJ V Ravetch

❮ Previous
Next ❯

Citations

Jun 8, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Bin LiuJames D Marks
Sep 30, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Mikael PerssonJörgen Carlsson
Dec 6, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Torun EngfeldtVladimir Tolmachev
Feb 13, 2008·European Journal of Nuclear Medicine and Molecular Imaging·M Jules Mattes, David M Goldenberg
Dec 11, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Vladimir TolmachevAnna Orlova
Jun 9, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Thuy A TranVladimir Tolmachev
Jul 14, 2010·Breast Cancer Research and Treatment·William G NorthBernard F Cole
Oct 20, 2009·Targeted Oncology·Gairin DanceyTim Meyer
Feb 9, 2011·Bioconjugate Chemistry·Susan HoppmannZhen Cheng
Sep 10, 2005·Nature Biotechnology·Anna M Wu, Peter D Senter
Sep 10, 2005·Nature Biotechnology·Philipp Holliger, Peter J Hudson
Oct 27, 2005·Cancer Biotherapy & Radiopharmaceuticals·Diane E MilenicMartin W Brechbiel
Nov 6, 2007·Cancer Biotherapy & Radiopharmaceuticals·Anna OrlovaVladimir Tolmachev
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew K RobinsonGregory P Adams
Jun 3, 2014·Theranostics·Matthias D'HuyvetterTony Lahoutte
Feb 17, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Matthias EderMichael Eisenhut
Dec 24, 2005·Expert Opinion on Drug Delivery·Vania Kenanova, Anna M Wu
Mar 31, 2010·Seminars in Nuclear Medicine·Tove Olafsen, Anna M Wu
Dec 17, 2009·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Martin HrubyMiroslav Vetrik
Jun 1, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·J L J Dearling, R B Pedley
May 23, 2009·British Journal of Pharmacology·Patrick ChamesDaniel Baty
Mar 28, 2008·Immunological Reviews·Xiao-yun LiuEllen S Vitetta
Jan 18, 2005·Biochemical and Biophysical Research Communications·Bao-Cheng HuangStephen J Kennel
Jul 11, 2006·Advanced Drug Delivery Reviews·Eveline Trachsel, Dario Neri
Dec 13, 2006·ChemMedChem·Jascha-N RybakDario Neri
Jan 14, 2009·Biopolymers·Torun EkbladAmelie Eriksson Karlström
Jun 26, 2009·Macromolecular Bioscience·Martin HrubyKarel Ulbrich
Oct 21, 2016·Chembiochem : a European Journal of Chemical Biology·Virginia J BruceBrian R McNaughton
Jul 29, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Achim RotheBarbara E Power
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ekaterina DadachovaArturo Casadevall
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rhona SteinDavid M Goldenberg
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dietmar BerndorffLudger M Dinkelborg
Mar 9, 2005·Cancer Research·Charles L VogelLeonard M Reyno
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ingrid BurvenichGuido Slegers
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert M SharkeyDavid M Goldenberg
Nov 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Habibe KaracayDavid M Goldenberg
Jan 20, 2021·Seminars in Cancer Biology·Vladimir TolmachevJens Sörensen
May 1, 2021·International Journal of Molecular Sciences·Sara S RinneVladimir Tolmachev
Mar 27, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Anna OrlovaVladimir Tolmachev
Feb 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Geraldine GebhartZena Wimana

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.