A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region.

Nature Communications
Jean Claude Semuto NgabonzizaPhilip Supply

Abstract

The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle.

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Citations

Oct 14, 2020·Transboundary and Emerging Diseases·Fermin AcostaDarío García de Viedma
Dec 16, 2020·FEMS Microbiology Reviews·Rhastin A D CastroSebastien Gagneux
Jan 15, 2021·Microorganisms·Ana Santos-PereiraNuno S Osório
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Oct 13, 2021·World Journal of Microbiology & Biotechnology·Azger DusthackeerBeena E Thomas

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Datasets Mentioned

BETA
AF2122/97
GM041182

Methods Mentioned

BETA
Illumina sequencing
genotyping
Assay
electrophoresis

Clinical Trials Mentioned

NCT03303963

Software Mentioned

Samtools
Microscope
BLAST
ClonalFrameML
Artemis tool
Artemis
RAxML
Mycobrowser
SeqPrep
VarScan

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