A Size-Reducible Nanodrug with an Aggregation-Enhanced Photodynamic Effect for Deep Chemo-Photodynamic Therapy

Angewandte Chemie
Chendong JiMeizhen Yin

Abstract

Fluorescent dyes with multi-functionality are of great interest for photo-based cancer theranostics. However, their low singlet oxygen quantum yield impedes their potential applications for photodynamic therapy (PDT). Now, a molecular self-assembly strategy is presented for a nanodrug with a remarkably enhanced photodynamic effect based on a dye-chemodrug conjugate. The self-assembled nanodrug possesses an increased intersystem crossing rate owing to the aggregation of dye, leading to a distinct singlet oxygen quantum yield (Φ(1 O2 )). Subsequently, upon red light irradiation, the generated singlet oxygen reduces the size of the nanodrug from 90 to 10 nm, which facilitates deep tumor penetration of the nanodrug and release of chemodrug. The nanodrug achieved in situ tumor imaging and potent tumor inhibition by deep chemo-PDT. Our work verifies a facile and effective self-assembly strategy to construct nanodrugs with enhanced performance for cancer theranostics.

References

Jul 6, 2000·Journal of Photochemistry and Photobiology. B, Biology·E DelaeyP de Witte
May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
Sep 1, 2005·Journal of the American Chemical Society·Takatoshi YogoTetsuo Nagano
Sep 1, 2006·Photomedicine and Laser Surgery·Anderson J GomesAntonio C Tedesco
Nov 10, 2009·Nature Nanotechnology·Andrew M SmithShuming Nie
Aug 10, 2010·Chemical Society Reviews·Manivannan EthirajanRavindra K Pandey
Sep 13, 2012·Molecular Pharmaceutics·Fabienne DanhierVéronique Préat
Feb 6, 2013·Journal of the American Chemical Society·Andrew G CheethamHonggang Cui
Aug 24, 2013·Accounts of Chemical Research·Bing WangWeiyue Feng
Aug 1, 2014·Journal of the American Chemical Society·Ping HuangDeyue Yan
Dec 17, 2014·Angewandte Chemie·Marcus SchulzeFrank Würthner
Mar 6, 2015·Journal of the American Chemical Society·Kaimin CaiJianjun Cheng
Mar 24, 2015·Chemical Communications : Chem Comm·Yanfeng ZhangJianjun Cheng
Jun 30, 2015·Chemical Society Reviews·Rajesh KumarJong Seung Kim
Aug 6, 2015·Chemical Reviews·Kenneth K Ng, Gang Zheng
Sep 26, 2015·Angewandte Chemie·Roger R NaniMartin J Schnermann
Mar 8, 2016·Advanced Materials·Chenggen QianZhen Gu
Jun 18, 2016·Chemical Reviews·Wen SunXiaojun Peng
Jun 28, 2016·Current Opinion in Chemical Biology·Alexander P Gorka, Martin J Schnermann
Oct 11, 2016·Chemical Society Reviews·Wenpei FanXiaoyuan Chen
Oct 28, 2017·Nature Reviews. Materials·Hongmin ChenXiaoyuan Chen
Oct 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chendong JiMeizhen Yin

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Citations

May 9, 2019·Advanced Healthcare Materials·Minhuan LanPengfei Wang
Jan 1, 2020·Chembiochem : a European Journal of Chemical Biology·Xing Qin, Yongsheng Li
Apr 22, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Xu TengBuhong Li
Sep 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mingdi SunPiaoping Yang
Oct 1, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bo-Ai Ma, Chun-Yang Sun
Dec 14, 2018·Frontiers in Endocrinology·Ayushi PriyamShweta Gehlout
Dec 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qi CaiPiaoping Yang
Dec 6, 2018·Pharmaceuticals·Tuanwei Li, Lifeng Yan
Oct 3, 2018·International Journal of Molecular Sciences·Ying WangZhe Yang
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongtao ChenMeizhen Yin
Dec 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rongrong NieHui Wang
Jan 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xuejin HuangHong Chen
Feb 10, 2021·Photodiagnosis and Photodynamic Therapy·Arshadul HakAravind Kumar Rengan
Mar 11, 2021·Biomaterials·Yuequan WangJin Sun
Sep 6, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lingling HuangJianqing Gao
Feb 26, 2021·Angewandte Chemie·Jun GuanRichard M Laine
Apr 22, 2021·Chemistry, an Asian Journal·Ying DingPengfei Wang
Apr 27, 2021·ACS Nano·Qiuhong ZhangYanli Zhao
May 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haotian LuAiguo Hu
Jun 12, 2021·Frontiers in Chemistry·Zhenyan HeLiang Luo
Jul 2, 2021·Frontiers in Chemistry·Xiang XiaXiaojun Peng

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