A SMAD4-modulated gene profile predicts disease-free survival in stage II and III colorectal cancer.

Cancer Reports
Bryan C SzeglinJ Joshua Smith

Abstract

Colorectal cancer is the second-leading cause of cancer-related mortality in the United States and a leading cause of cancer-related mortality worldwide. Loss of SMAD4, a critical tumor suppressor and the central node of the transforming growth factor-beta superfamily, is associated with worse outcomes for colorectal cancer patients; however, it is unknown whether an RNA-based profile associated with SMAD4 expression could be used to better identify high-risk colorectal cancer patients. Identify a gene expression-based SMAD4-modulated profile and test its association with patient outcome. Using a discovery dataset of 250 colorectal cancer patients, we analyzed expression of BMP/Wnt target genes for association with SMAD4 expression. Promoters of the BMP/Wnt genes were interrogated for SMAD-binding elements. Fifteen genes were implicated and three tested for modulation by SMAD4 in patient-derived colorectal cancer tumoroids. Expression of the 15 genes was used for unsupervised hierarchical clustering of a training dataset and two resulting clusters modeled in a centroid model. This model was applied to an independent validation dataset of stage II and III patients. Disease-free survival was analyzed by the Kaplan-Meier method. I...Continue Reading

References

Jul 10, 2001·Acta Oncologica·P RagnhammarUNKNOWN SBU-group. Swedish Council of Technology Assessment in Health Care
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert TibshiraniGilbert Chu
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hafid AlazzouziDiego Arango
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pia AlhopuroDiego Arango
Apr 25, 2006·Biostatistics·W Evan JohnsonAriel Rabinovic
Feb 27, 2007·Gastroenterology·Laurens G Van der FlierHans Clevers
May 13, 2008·Gastroenterology·Brian M Wolpin, Robert J Mayer
Nov 19, 2008·PathoGenetics·Paola AlbericiRiccardo Fodde
Aug 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J O'ConnellNorman Wolmark
Jul 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Monica M BertagnolliRobert S Warren
Nov 26, 2011·Gastroenterology·Tanner J FreemanR Daniel Beauchamp
Jun 20, 2012·International Journal of Colorectal Disease·Morten ThorsteinssonJørgen Olsen
Aug 25, 2012·Omics : a Journal of Integrative Biology·Sophy LaibeUNKNOWN COL2 Project
Feb 1, 2014·Nature Methods·Florian HeigwerMichael Boutros
Jul 31, 2014·Nature Methods·Neville E SanjanaFeng Zhang
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 24, 2015·Nature Genetics·Claudio IsellaEnzo Medico
Feb 24, 2015·Nature Genetics·Alexandre CalonEduard Batlle
Mar 10, 2015·Translational Oncology·Philip W VoorneveldJames C H Hardwick
Apr 30, 2015·Nature·Jarno DrostHans Clevers
Oct 13, 2015·Nature Medicine·Justin GuinneySabine Tejpar
Feb 11, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Pu YanRoberto Fiocca
Mar 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Arianna FumagalliJacco van Rheenen
Mar 10, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Al B BensonDeborah Freedman-Cass
Dec 28, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Isaac WassermanJ Joshua Smith
Oct 9, 2019·Nature Medicine·Karuna GaneshJ Joshua Smith

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