A Small Molecule Spinogenic Compound Enhances Functional Outcome and Dendritic Spine Plasticity in a Rat Model of Traumatic Brain Injury.

Journal of Neurotrauma
Yanlu ZhangYe Xiong

Abstract

The tetra (ethylene glycol) derivative of benzothiazole aniline (SPG101) has been shown to improve dendritic spine density and cognitive memory in the triple transgenic mouse model of Alzheimer disease (AD) when administered intraperitoneally. The present study was designed to investigate the therapeutic effects of SPG101 on dendritic spine density and morphology and sensorimotor and cognitive functional recovery in a rat model of traumatic brain injury (TBI) induced by controlled cortical impact (CCI). Young adult male Wistar rats with CCI were randomly divided into the following two groups (n = 7/group): (1) Vehicle, and (2) SPG101. SPG101 (30 mg/kg) dissolved in vehicle (1% dimethyl sulfoxide in phosphate buffered saline) or Vehicle were intraperitoneally administered starting at 1 h post-injury and once daily for the next 34 days. Sensorimotor deficits were assessed using a modified neurological severity score and adhesive removal and foot fault tests. Cognitive function was measured by Morris water maze, novel object recognition (NOR), and three-chamber social recognition tests. The animals were sacrificed 35 days after injury, and their brains were processed for measurement of dendritic spine density and morphology using ...Continue Reading

References

Mar 22, 2001·Nature Reviews. Neuroscience·J C Magee
Jan 25, 2005·Mental Retardation and Developmental Disabilities Research Reviews·Jacqueline N Crawley
May 24, 2005·Neuropharmacology·Alan I FadenIbolja Cernak
Apr 20, 2006·Journal of Neuroscience Methods·Se Hoon ChoiTimothy Schallert
Dec 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nobuaki YasumatsuHaruo Kasai
May 22, 2010·Journal of Neurosurgery·Ye XiongMichael Chopp
Aug 25, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael A PattersonRyohei Yasuda
Dec 24, 2010·British Journal of Pharmacology·Niklas Marklund, Lars Hillered
Jan 7, 2011·The International Journal of Neuropsychopharmacology·Zelda H Cheung, Nancy Y Ip
Feb 5, 2011·Journal of Neuropathology and Experimental Neurology·Xiang Gao, Jinhui Chen
Aug 16, 2011·Journal of Neurotrauma·John N CampbellSevern B Churn
Jul 14, 2012·EMBO Reports·Nathalie L Rochefort, Arthur Konnerth
Aug 15, 2012·Journal of Neurotrauma·Bridgette D SempleLinda J Noble-Haeusslein
Jan 19, 2013·Nature Reviews. Neuroscience·Ye XiongMichael Chopp
May 31, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea MegillHyang-Sook Hoe
Aug 2, 2013·Optics Letters·Colin J R SheppardRainer Heintzmann
Feb 1, 2014·Journal of Neurotrauma·Lora Talley WattsTimothy Q Duong
Apr 15, 2014·Nature Medicine·Kristie T OtaRonald S Duman
Jun 11, 2014·Biochimica Et Biophysica Acta·Saman Ebrahimi, Shigeo Okabe
Aug 30, 2014·Behavioural Brain Research·Sarah J Cohen, Robert W Stackman
Jan 24, 2015·Journal of Neurosurgery·Yanlu ZhangYe Xiong
Mar 3, 2015·Expert Opinion on Investigational Drugs·Ye XiongMichael Chopp
Jun 21, 2015·Hormones and Behavior·Michael P ReillyAndrea C Gore

❮ Previous
Next ❯

Citations

May 16, 2019·Neural Regeneration Research·Ye XiongMichael Chopp
Nov 6, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Laura Trujillo-EstradaFrank M LaFerla

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
confocal microscopy
GTPases

Software Mentioned

SPSS
ZEN
Airyscan
Afraxis ESP

Related Concepts

Related Feeds

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.