A small world of neuronal synchrony.

Cerebral Cortex
Shan YuDanko Nikolic

Abstract

A small-world network has been suggested to be an efficient solution for achieving both modular and global processing-a property highly desirable for brain computations. Here, we investigated functional networks of cortical neurons using correlation analysis to identify functional connectivity. To reconstruct the interaction network, we applied the Ising model based on the principle of maximum entropy. This allowed us to assess the interactions by measuring pairwise correlations and to assess the strength of coupling from the degree of synchrony. Visual responses were recorded in visual cortex of anesthetized cats, simultaneously from up to 24 neurons. First, pairwise correlations captured most of the patterns in the population's activity and, therefore, provided a reliable basis for the reconstruction of the interaction networks. Second, and most importantly, the resulting networks had small-world properties; the average path lengths were as short as in simulated random networks, but the clustering coefficients were larger. Neurons differed considerably with respect to the number and strength of interactions, suggesting the existence of "hubs" in the network. Notably, there was no evidence for scale-free properties. These resu...Continue Reading

References

Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C M Gray, W Singer
Aug 1, 1981·Journal of Neurophysiology·K ToyamaK Tanaka
Aug 1, 1997·Current Opinion in Neurobiology·H Sompolinsky, R Shapley
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·P FriesW Singer
Jun 12, 1998·Nature·D J Watts, S H Strogatz
Oct 16, 1999·Science·A L Barabasi, R Albert
Mar 7, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K E StephanR Kötter
Jun 9, 2000·Annual Review of Neuroscience·D Ferster, K D Miller
Aug 10, 2000·Nature·R AlbertA L Barabasi
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·L A AmaralH E Stanley
Oct 4, 2000·Physical Review Letters·L F Lago-FernándezJ A Sigüenza
Feb 16, 2002·Journal of Theoretical Biology·Jose M Montoya, Ricard V Sol
Feb 11, 2003·Neuron·Mark J Schnitzer, Markus Meister
Dec 20, 2003·Physical Review Letters·Elad SchneidmanWilliam Bialek
Mar 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·A BarratA Vespignani
Aug 21, 2004·Neuroinformatics·Olaf Sporns, Jonathan D Zwi
Sep 8, 2004·Trends in Cognitive Sciences·Olaf SpornsClaus C Hilgetag
Sep 15, 2004·Neuroinformatics·Claus C Hilgetag, Marcus Kaiser
Jan 12, 2005·Neuroscience and Biobehavioral Reviews·Andrew A FingelkurtsSeppo Kähkönen
Feb 9, 2005·Physical Review Letters·Victor M EguíluzA Vania Apkarian
Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael P H StumpfRobert M May
May 21, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Debin Huang
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sophie AchardEd Bullmore
Feb 3, 2006·Cerebral Cortex·C J StamPh Scheltens
Apr 18, 2006·Proceedings. Biological Sciences·M D HumphriesT J Prescott
Aug 1, 2006·Schizophrenia Research·Sifis MicheloyannisMichael Zervakis
Aug 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jonathon ShlensE J Chichilnisky
Nov 3, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Danielle Smith Bassett, Ed Bullmore
Dec 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Timothy R LezonNina V Fedoroff
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Danielle S BassettEdward Bullmore
Feb 6, 2007·PLoS Computational Biology·Sophie Achard, Ed Bullmore
Mar 16, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Luís M A BettencourtGuenter W Gross
Jun 9, 2007·Trends in Neurosciences·Pascal FriesWolf Singer
Jun 15, 2007·The European Journal of Neuroscience·Marcus KaiserMalcolm P Young
Jan 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aonan TangJohn M Beggs

❮ Previous
Next ❯

Citations

Nov 7, 2008·Journal of Computational Neuroscience·Chin-Yueh Liu, Duane Q Nykamp
Jul 17, 2010·Journal of Computational Neuroscience·Ifije E Ohiorhenuan, Jonathan D Victor
Jan 22, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mehran AhmadlouEsfandiar Azad-Marzabadi
Jul 6, 2010·Nature·Ifije E OhiorhenuanJonathan D Victor
Jan 24, 2013·Nature Communications·Takamitsu WatanabeNaoki Masuda
Dec 8, 2009·Nature Neuroscience·Wilson TruccoloJohn P Donoghue
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Apr 14, 2012·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Naoya TakahashiYuji Ikegaya
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Greg J StephensWilliam Bialek
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lazaros K GallosMariano Sigman
Mar 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·William BialekAleksandra M Walczak
Dec 20, 2012·Brain Connectivity·Yasser Iturria-Medina
Aug 1, 2012·Neural Computation·Feraz Azhar, William S Anderson
Apr 24, 2013·Neural Computation·Robert HaslingerEmery Brown
Feb 25, 2011·Neurosurgery·Alessandro De Benedictis, Hugues Duffau
Dec 23, 2009·PLoS Biology·Danko NikolićWolfgang Maass
Jan 20, 2010·PLoS Biology·Tara C ThiagarajanDietmar Plenz
May 23, 2012·PLoS Computational Biology·Julia H DownesSlawomir J Nasuto
Apr 5, 2013·PLoS Computational Biology·Viola PriesemannMichel Le Van Quyen
Jan 7, 2014·PLoS Computational Biology·Gašper TkačikMichael J Berry
May 17, 2012·PloS One·Guillaume DumasJacques Martinerie
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elad SchneidmanMichael J Berry
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael OkunKenneth D Harris
Jul 6, 2014·PLoS Computational Biology·Urs KösterBruno A Olshausen
Mar 14, 2014·Cognitive Neurodynamics·Jingyi QuYing Du
Jun 20, 2014·Brain Connectivity·Walter S PritchardSatoru Hayasaka
Dec 7, 2010·Annual Review of Clinical Psychology·Edward T Bullmore, Danielle S Bassett
Nov 6, 2014·Molecular Autism·Rachel C LeungSam M Doesburg
Feb 24, 2016·Annals of Clinical and Translational Neurology·Elizabeth W PangMargot J Taylor
Feb 3, 2016·Scientific Reports·Anusha MohanSven Vanneste
Jan 23, 2016·Scientific Reports·Johanne HizanidisChris G Antonopoulos
May 2, 2013·Neural Networks : the Official Journal of the International Neural Network Society·Antonio G ZippoGabriele E M Biella
Feb 2, 2016·Chaos·Chris G Antonopoulos
Mar 15, 2016·Frontiers in Bioengineering and Biotechnology·Sankaraleengam AlagapanThomas B DeMarse
Sep 25, 2015·Journal of Cognitive Neuroscience·Sam M DoesburgElizabeth W Pang
May 15, 2015·Neurobiology of Disease·Karim G Oweiss, Islam S Badreldin

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA

Software Mentioned

Pajek
LabView
ActiveSTIM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Sophie AchardEd Bullmore
Proceedings of the National Academy of Sciences of the United States of America
Danielle Smith BassettEdward T Bullmore
Neuroinformatics
O Sporns, Jonathan D Zwi
© 2022 Meta ULC. All rights reserved