A smart all-in-one theranostic platform for CT imaging guided tumor microwave thermotherapy based on IL@ZrO2 nanoparticles

Chemical Science
Haitang ShiXianwei Meng

Abstract

This study develops a simple hollow ZrO2 nanostructure as a carrier to encapsulate ionic liquid (IL), which integrates the CT imaging function of the ZrO2 shell and the microwave susceptibility function of the IL core. The simple nanostructure can be used as a multifunctional theranostic agent via combining diagnostic and therapeutic modalities into one "package". Based on the microwave susceptibility properties, the tumor inhibiting ratio can be over 90% in mice models after one-time thermal therapy upon microwave irradiation. In vitro and in vivo imaging results prove the potential of CT imaging application for real-time monitoring of biodistribution and metabolic processes, and assessing therapeutic outcomes. To our best knowledge, our study is the first example to achieve CT imaging and microwave thermal therapy simultaneously through a simple nanostructure. We anticipate that the simple IL@ZrO2 nanostructure may build a useful platform for the clinical imaging guided therapy of tumors.

References

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Citations

Jan 4, 2019·Nanoscale·Xiangjun HanKhashayar Farsad
Feb 19, 2019·Small·Huijing Xiang, Yu Chen
Oct 17, 2019·Chemical Communications : Chem Comm·Taya TangTianlong Liu
Mar 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shengping WangXianwei Meng
Jun 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jingyun WangXiaodan Sun
Mar 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tao ZhangZhigang Xie
Nov 1, 2018·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Qiong WuXianwei Meng
Dec 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shunsong TangXianwei Meng
Nov 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Peipei JiaPiaoping Yang
Jul 28, 2017·ACS Applied Materials & Interfaces·Haiqing WangXun Wang
Oct 28, 2021·Biomacromolecules·Sudath HapuarachchigeDmitri Artemov

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Methods Mentioned

BETA
X-ray
transmission electron microscopy
infrared spectroscopy
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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