A Snapshot of the Plant Glycated Proteome: STRUCTURAL, FUNCTIONAL, AND MECHANISTIC ASPECTS.

The Journal of Biological Chemistry
Tatiana BilovaAndrej Frolov

Abstract

Glycation is the reaction of carbonyl compounds (reducing sugars and α-dicarbonyls) with amino acids, lipids, and proteins, yielding early and advanced glycation end products (AGEs). The AGEs can be formed via degradation of early glycation intermediates (glycoxidation) and by interaction with the products of monosaccharide autoxidation (autoxidative glycosylation). Although formation of these potentially deleterious compounds is well characterized in animal systems and thermally treated foods, only a little information about advanced glycation in plants is available. Thus, the knowledge of the plant AGE patterns and the underlying pathways of their formation are completely missing. To fill this gap, we describe the AGE-modified proteome ofBrassica napusand characterize individual sites of advanced glycation by the methods of liquid chromatography-based bottom-up proteomics. The modification patterns were complex but reproducible: 789 AGE-modified peptides in 772 proteins were detected in two independent experiments. In contrast, only 168 polypeptides contained early glycated lysines, which did not resemble the sites of advanced glycation. Similar observations were made withArabidopsis thaliana The absence of the early glycated...Continue Reading

References

Jan 15, 1988·The Biochemical Journal·S P Wolff, R T Dean
Nov 12, 1996·Biochemical and Biophysical Research Communications·Y HamadaN Hotta
Jul 21, 1999·Biochemical Pharmacology·E A AbordoP J Thornalley
Jun 9, 2000·Kidney International·M F WeissV M Monnier
Oct 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C ZoccaliG Tripepi
Mar 10, 2001·Recent Progress in Hormone Research·P Ulrich, A Cerami
Sep 11, 2003·Journal of Biochemistry·Yasuo YamauchiKiyoshi Tanaka
Jan 1, 1955·Advances in Carbohydrate Chemistry·J E HODGE
Feb 12, 2005·The Biochemical Journal·Juliette FortpiedEmile van Schaftingen
Nov 3, 2005·Journal of Experimental Botany·Chenghong HuangLixin Zhang
May 16, 2006·Carbohydrate Research·Paola ManiniMarco d'Ischia
Mar 28, 2007·Transgenic Research·Sneh L Singla-PareekS K Sopory
Nov 15, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·LeAnn M SnowLaDora V Thompson
Dec 8, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Nicholas A CellarScott A Young
Apr 10, 2008·Journal of Proteome Research·Qibin ZhangThomas O Metz
May 2, 2008·Annals of the New York Academy of Sciences·Naila Rabbani, Paul J Thornalley
May 2, 2008·Annals of the New York Academy of Sciences·Andrej Frolov, Ralf Hoffmann
Apr 28, 2009·The Plant Journal : for Cell and Molecular Biology·Ulrike BechtoldPaul J Thornalley
May 19, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Richard D SembaLuigi Ferrucci
May 25, 2010·Analytical and Bioanalytical Chemistry·Andrej Frolov, Ralf Hoffmann
Jan 19, 2012·Nutrients·Claudia Luevano-Contreras, Karen Chapman-Novakofski
May 26, 2012·Biochimie·Jennifer Baraka-VidotPhilippe Rondeau
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Malene W PoulsenLars O Dragsted
Apr 15, 2014·Journal of Agricultural and Food Chemistry·Andrej FrolovRalf Hoffmann
Jul 11, 2014·Journal of Proteome Research·Ravi Chand BollineniRalf Hoffmann
Mar 25, 2015·Journal of Mass Spectrometry : JMS·Rico SchmidtAndrej Frolov
Jun 6, 2015·Journal of Agricultural and Food Chemistry·Sanja Milkovska-StamenovaClaudia Birkemeyer

❮ Previous
Next ❯

Citations

Nov 29, 2017·International Journal of Molecular Sciences·Alena SobolevaAndrej Frolov
Oct 6, 2018·Angewandte Chemie·Nicole M SjoblomRebecca A Scheck
Nov 16, 2018·Molecular Nutrition & Food Research·Sanja Milkovska-StamenovaRalf Hoffmann
Dec 19, 2018·International Journal of Molecular Sciences·Tatiana MamontovaAndrej Frolov
Nov 6, 2018·Journal of Experimental Botany·Amanda K ChaplinUlrike Bechtold
Dec 20, 2018·International Journal of Molecular Sciences·Natalia OsmolovskayaLudger A Wessjohann
Nov 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Stefan FritzscheClaudia Birkemeyer
Jul 31, 2019·International Journal of Molecular Sciences·Kristina AntonovaAndrej Frolov
Nov 20, 2016·Journal of Experimental Botany·Gagan PaudelAndrej Frolov
Mar 2, 2017·Proteomes·Akiko Hashiguchi, Setsuko Komatsu
Dec 13, 2017·International Journal of Molecular Sciences·Alena SobolevaAndrej Frolov
Mar 1, 2018·Functional Plant Biology : FPB·Andrej FrolovSergei Medvedev
May 16, 2019·International Journal of Molecular Sciences·Julia ShumilinaAndrej Frolov
Dec 5, 2020·International Journal of Molecular Sciences·Galina SmolikovaAndrej Frolov
Dec 31, 2020·International Journal of Molecular Sciences·Galina SmolikovaSergei Medvedev
Jun 5, 2021·Nature Communications·Joseph M McEwenRebecca A Scheck

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
gel filtration
Acid
environmental stress
glycosylation

Software Mentioned

Sequest
Xcalibur
MassLynx
MapMan
MarkerView
Analyst TF
MultiQuant

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.