A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sodium channel sensitivity to type I, but not type II pyrethroids

Insect Biochemistry and Molecular Biology
Zhaonong HuKe Dong

Abstract

Voltage-gated sodium channels are the primary target of pyrethroid insecticides. Numerous point mutations in sodium channel genes have been identified in pyrethroid-resistant insect species, and many have been confirmed to reduce or abolish sensitivity of channels expressed in Xenopus oocytes to pyrethroids. Recently, several novel mutations were reported in sodium channel genes of pyrethroid-resistant Aedes mosquito populations. One of the mutations is a phenylalanine (F) to cysteine (C) change in segment 6 of domain III (IIIS6) of the Aedes mosquito sodium channel. Curiously, a previous study showed that alanine substitution of this F did not alter the action of deltamethrin, a type II pyrethroid, on a cockroach sodium channel. In this study, we changed this F to C in a pyrethroid-sensitive cockroach sodium channel and examined mutant channel sensitivity to permethrin as well as five other type I or type II pyrethroids in Xenopus oocytes. Interestingly, the F to C mutation drastically reduced channel sensitivity to three type I pyrethroids, permethrin, NRDC 157 (a deltamethrin analogue lacking the α-cyano group) and bioresemthrin, but not to three type II pyrethroids, cypermethrin, deltamethrin and cyhalothrin. These results ...Continue Reading

References

Jan 9, 2007·Invertebrate Neuroscience : in·Ke Dong
May 10, 2007·IUBMB Life·T G Emyr DaviesMartin S Williamson

Citations

Jul 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yuzhe DuKe Dong
Apr 8, 2014·Insect Biochemistry and Molecular Biology·Ke DongBoris S Zhorov
Mar 17, 2012·Journal of Economic Entomology·Jerome J Schleier, Robert K D Peterson
Sep 11, 2013·Pesticide Biochemistry and Physiology·Frank D RinkevichKe Dong
Feb 6, 2015·Pest Management Science·Aleksandra Obrępalska-StęplowskaBarbara Wrzesińska
Jun 7, 2011·Insect Biochemistry and Molecular Biology·Mark J BurtonMartin S Williamson
Apr 10, 2015·Parasitology Research·Govindaraju Ramkumar, Muthugoundar S Shivakumar
May 8, 2020·Archives of Insect Biochemistry and Physiology·Mengli ChenKe Dong
Jul 26, 2017·PLoS Neglected Tropical Diseases·Gonçalo SeixasCarla Alexandra Sousa
Aug 20, 2016·Journal of Pesticide Science·Koichi Hirata
Feb 7, 2019·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Shinji KasaiTakashi Tomita

Related Concepts

Aedes
Polyphagidae
Cysteine Hydrochloride
Insecticide Resistance
Insecticides
Oocytes
Endorphenyl
Pyrethroids
Proteins, Recombinant DNA
Sodium

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