A software program for quantitative analysis of alveolar oxygen partial pressure (p(A)O(2)) with oxygen-sensitive (3)He-MRI

RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
F LehmannWolfgang G Schreiber

Abstract

To develop a software tool for quantitative analysis of alveolar oxygen partial pressure (p(A)O(2)) as well as its time course during apnea. T (1)-relaxation times of hyperpolarized (3)He are reduced by paramagnetic oxygen rendering (3)He-MRI sensitive to oxygen and thus allowing the assessment of the local oxygen partial pressure in the pulmonary airspaces. Oxygen-related relaxation and loss of polarization by RF-excitation can be discriminated by acquiring two image series with varying interscan delay and/or flip angles. Software was developed to calculate the p(A)O(2) and the decay rate in user-defined regions of interest (ROIs) automatically. Moreover, parameter maps can be calculated. In addition to the analysis of 2-dimensional data sets, the software allows the evaluation of 3-dimensional measurements for the first time. Artifacts due to lung motion were reduced by implementing a motion correction algorithm. The software was successfully applied to data sets from healthy volunteers and from patients with various lung diseases. The parameter maps demonstrated a more homogeneous distribution of p(A)O(2) for the volunteers than for the patients. A regional increase in p(A)O(2) was found in a few patients. The described soft...Continue Reading

Citations

Jul 29, 2009·Der Radiologe·K K Gast, U Wolf
May 1, 2010·Pediatric Radiology·Michael Puderbach, Monika Eichinger
Apr 28, 2005·European Radiology·Klaus Kurt GastBalthasar Eberle
Jul 14, 2006·European Radiology·Karl-Friedrich KreitnerChristoph Düber
Oct 11, 2007·European Radiology·Klaus Kurt GastBalthasar Eberle
Jun 20, 2007·Antioxidants & Redox Signaling·J F Dunn

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