A software tool for analysis and quantification of regional pulmonary ventilation using dynamic hyperpolarised-(3)He-MRI

RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
F LehmannW G Schreiber

Abstract

(3)He-MRI is able to visualize the regional distribution of lung ventilation with a temporal and spatial resolution so far unmatched by any other technique. The aim of the study was the development of a new software tool for quantification of dynamic ventilation parameters in absolute physical units. During continuous breathing, a bolus of hyperpolarized (3)He (300 ml) was applied at inspiration and a series of 168 coronal projection images simultaneously acquired using a 2D FLASH-sequence. Postprocessing software was developed to analyze the (3)He distribution in the lung. After correction for lung motion, several ventilation parameters (rise time, delay time, (3)He amount and (3)He peak flow) were calculated. Due to normalization of signal intensities, these parameters are presented in absolute physical units. The data sets were analyzed on a ROI basis as well as on a pixel-by-pixel basis. Using the developed software, the measurements were analyzed in 6 lung-healthy volunteers, in one patient after lung transplantation, and in one patient with lung emphysema. The volunteers' parameter maps of the pixel-based analysis showed an almost homogeneous distribution of the ventilation parameters within the lung. In the parameter map...Continue Reading

Citations

Jul 29, 2009·Der Radiologe·K K Gast, U Wolf
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Nov 26, 2010·Journal of Magnetic Resonance Imaging : JMRI·Monika EichingerMichael Puderbach
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