A solid frame for the window on cognition: Modeling event-related pupil responses.

Journal of Vision
Christoph W Korn, Dominik R Bach

Abstract

Pupil size is often used to infer central processes, including attention, memory, and emotion. Recent research has spotlighted its relation to behavioral variables from decision-making models and to neural variables such as locus coeruleus activity and cortical oscillations. As yet, a unified and principled approach for analyzing pupil responses is lacking. Here we seek to establish a formal, quantitative forward model for pupil responses by describing them with linear time-invariant systems. Based on empirical data from human participants, we show that a combination of two linear time-invariant systems can parsimoniously explain approximately all variance evoked by illuminance changes. Notably, the model makes a counterintuitive prediction that pupil constriction dominates the responses to darkness flashes, as in previous empirical reports. This prediction was quantitatively confirmed for responses to light and darkness flashes in an independent group of participants. Crucially, illuminance- and nonilluminance-related inputs to the pupillary system are presumed to share a common final pathway, composed of muscles and nerve terminals. Hence, we can harness our illuminance-based model to estimate the temporal evolution of this n...Continue Reading

Citations

Oct 19, 2016·Psychophysiology·Saurabh KhemkaDominik R Bach
Dec 8, 2016·Psychophysiology·Christoph W KornDominik R Bach
Apr 7, 2017·ELife·Jan Willem de GeeTobias H Donner
Sep 1, 2018·PLoS Computational Biology·Athina TzovaraDominik R Bach
Sep 4, 2018·Psychophysiology·Dominik R BachTobias Moser
Sep 27, 2018·Trends in Hearing·Adriana A ZekveldSophia E Kramer
Dec 1, 2018·PLoS Computational Biology·Joanne C Van SlootenJan Theeuwes
Aug 20, 2019·Psychophysiology·Charlotte PietrockFlorian Schlagenhauf
Mar 29, 2020·Frontiers in Neuroscience·Andy SchumannKarl Jürgen Bär
Mar 8, 2020·Behavior Research Methods·Rachel N DenisonMarisa Carrasco
Sep 14, 2018·Scientific Reports·Olympia ColizoliTobias H Donner
Apr 8, 2021·Journal of Biomedical Informatics·Hedenir Monteiro Pinheiro, Ronaldo Martins da Costa

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