A solid-state NMR study of the dynamics and interactions of phenylalanine rings in a statherin fragment bound to hydroxyapatite crystals

Journal of the American Chemical Society
James M GibsonGary P Drobny

Abstract

Extracellular matrix proteins regulate hard tissue growth by acting as adhesion sites for cells, by triggering cell signaling pathways, and by directly regulating the primary and/or secondary crystallization of hydroxyapatite, the mineral component of bone and teeth. Despite the key role that these proteins play in the regulation of hard tissue growth in humans, the exact mechanism used by these proteins to recognize mineral surfaces is poorly understood. Interactions between mineral surfaces and proteins very likely involve specific contacts between the lattice and the protein side chains, so elucidation of the nature of interactions between protein side chains and their corresponding inorganic mineral surfaces will provide insight into the recognition and regulation of hard tissue growth. Isotropic chemical shifts, chemical shift anisotropies (CSAs), NMR line-width information, (13)C rotating frame relaxation measurements, as well as direct detection of correlations between (13)C spins on protein side chains and (31)P spins in the crystal surface with REDOR NMR show that, in the peptide fragment derived from the N-terminal 15 amino acids of salivary statherin (i.e., SN-15), the side chain of the phenylalanine nearest the C-te...Continue Reading

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Citations

Sep 26, 2008·Chemical Reviews·Lijun Wang, George H Nancollas
May 9, 2012·Journal of the American Chemical Society·Tobias WeidnerDavid G Castner
Aug 15, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Moise NdaoGary P Drobny
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Dec 25, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tailin GuoJie Weng
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Sep 22, 2012·Chemistry : a European Journal·Alessio AdamianoGiorgio Sartor
Nov 8, 2008·Journal of the American Chemical Society·Albert RimolaPiero Ugliengo
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Oct 13, 2007·Journal of the American Chemical Society·Kosta MakrodimitrisJeffrey J Gray

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