A soluble cadmium-binding component in rat and dog spleen.

Archives of Environmental Health
D E Amacher, K L Ewing

Abstract

The spleens of cadmium-treated Sprague-Dawley rats and mongrel dogs were examined for cytoplasmic soluble cadmium-binding moieties following the cessation of parenteral cadmium exposure. Cell homogenates prepared in 0.25M sucrose were centrifuged at 29,000 g and the supernatant fractionated on a fractionating column (Sephadex G-75). Ultraviolet absorbing peaks that showed characteristically high 250-nm to 280-nm absorbences were further analyzed for cadmium content by atomic absorption spectrophotometry. Cadmium-binding fractions isolated from the spleens of both species were characteristically similar to rat kidney metallothionein-like substances isolated and identified by the same procedure. Molecular weights for the canine and rat spleen cadmium-binding components were estimated at 14,783 +/- 343 and 13,916 +/- 490, respectively. These preliminary data indicate the production and persistence of soluble metallothionein-like substances in spleen that bind and retain cadmium ions long after cadmium exposure has ceased.

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Citations

Jan 1, 1980·Chemico-biological Interactions·B A Hart, R F Keating
Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·H KitoT Ishikawa
Apr 1, 1983·Journal of Toxicology and Environmental Health·K T SuzukiY K Yamada

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