A soluble flavonoid-glycoside, alphaG-rutin, is absorbed as glycosides in the isolated gastric and intestinal mucosa

Bioscience, Biotechnology, and Biochemistry
Megumi MatsumotoHiroshi Hara

Abstract

We investigated the absorption and metabolism of the highly soluble quercetin glycoside alphaG-rutin, a glucose adduct of insoluble rutin, using the isolated mucosa of the rat stomach and intestines equipped with the Ussing chamber. alphaG-rutin and rutin appeared in the serosal sides of the gastric body and all the intestinal mucosa after the addition of alphaG-rutin (1 mM) to the mucosal fluid. The degree of alphaG-rutin appearance was much lower in the gastric fundus than in the other parts. Quercetin was not found in the mucosal fluid of any mucosal specimen. The concentrations (microM) of alphaG-rutin and rutin in the serosal fluid as a result of transport from the mucosal side increased time-dependently and linearly with mucosal alphaG-rutin concentration (1, 10 or 100 mM). The highest transport was shown in the ileal mucosa. These results indicate that alphaG-rutin is partly hydrolyzed to rutin through the intestine and absorbed as such.

References

Jan 1, 1989·The American Journal of Chinese Medicine·I M Liu, S J Sheu
Dec 1, 1995·The American Journal of Clinical Nutrition·P C HollmanM B Katan
Jul 1, 1995·The Journal of Nutrition·C ManachC Rémésy
Jul 9, 1998·Free Radical Biology & Medicine·J M GeeI T Johnson
Aug 28, 1998·Bioscience, Biotechnology, and Biochemistry·K IokuJ Terao
Nov 21, 2001·Journal of Agricultural and Food Chemistry·J A VinsonP Bose
Jan 24, 2002·Journal of Agricultural and Food Chemistry·Vanessa CrespyChristian Remesy
Jan 9, 2003·Free Radical Research·A R RechnerC A Rice-Evans
Jan 23, 2003·Journal of Agricultural and Food Chemistry·Hiroyuki SakakibaraKazuki Kanazawa

❮ Previous
Next ❯

Citations

Feb 8, 2008·Bioscience, Biotechnology, and Biochemistry·Megumi MatsumotoHiroshi Hara
Feb 9, 2010·Bioscience, Biotechnology, and Biochemistry·Guo XieHiroshi Kurihara
Apr 15, 2006·The Journal of Nutrition·Sophie LafayAugustin Scalbert
Jan 8, 2021·Frontiers in Microbiology·Alessandra RivaDavid Berry
Sep 6, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M SilberbergC Morand
Apr 21, 2007·Journal of Agricultural and Food Chemistry·Megumi MatsumotoHiroshi Hara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.