PMID: 7023694Jul 1, 1981Paper

A somatomedin-like peptide hormone is required during the estrogen-mediated induction of ovalbumin gene transcription

Cell
M I EvansG S McKnight

Abstract

Expression of the ovalbumin gene in chicken oviduct explant cultures requires the presence of a somatomedin-like peptide hormone in addition to estrogen. Insulin, proinsulin and multiplication-stimulating activity (MSA) are equally active substitutes for this peptide hormone, and maximal induction requires about 0.5 micrograms/ml; fetal calf serum can partially substitute for these factors. The equipotency of insulin and proinsulin indicates that insulin receptors are not involved, and the activity of MSA suggests that the active receptor is specific for somatomedins. The permissive effect of the peptide factor occurs within 1-2 hr and is required for the initiation of estrogen-mediated transcription on the ovalbumin gene. In contrast, transcription from the conalbumin gene is fully induced by estrogen in the presence or absence of peptide factors or serum, despite the fact that these two egg white genes are both transcribed in the same cells in response to the same steroid hormones. We suggest that the interaction of a somatomedin with its membrane-bound receptor generates an intracellular signal that interacts specifically with the ovalbumin gene.

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D T Kurtz, P Feigelson
Jun 11, 1979·Nucleic Acids Research·M CochetR Palmiter
May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·M M RechlerL Fryklund
Jan 1, 1977·Annual Review of Biochemistry·M P Czech
Jan 1, 1978·Cold Spring Harbor Symposia on Quantitative Biology·G SchützA E Sippel
Jan 1, 1978·Cold Spring Harbor Symposia on Quantitative Biology·R D PalmiterA W Senear
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G E SwaneckB W O'Malley
Jun 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R D Palmiter, N H Carey
Aug 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·W G JuergensJ J Elias
Jan 1, 1980·European Journal of Biochemistry·A C MosesM M Rechler
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A C MosesO Z Higa
Dec 1, 1980·Cell·D Barnes, G Sato

❮ Previous
Next ❯

Citations

Dec 1, 1989·Experimental Cell Research·T BarkaE W Gresik
Jun 1, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·T K Joensuu
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·S SalomaaP Tuohimaa
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·F F BolanderY J Topper
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D B Pritchett, J L Roberts
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M I EvansJ B Burch
Jan 24, 1986·Nucleic Acids Research·B W Birren, H R Herschman
Dec 5, 1982·Journal of Molecular Biology·P GerlingerP Chambon
Jan 1, 1985·Diabetes/metabolism Reviews·D K Granner, T L Andreone
May 15, 1985·Archives of Biochemistry and Biophysics·R L FoldesE Bresnick
Feb 1, 1985·Journal of Dairy Science·L M HoudebineJ L Servely

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.