A spatial model of the human airway tree: the hybrid conceptual model

Journal of Aerosol Medicine and Pulmonary Drug Delivery
Spyridon MontesantosLivia Tossici-Bolt

Abstract

The conceptual model of the lung describes the spatial distribution of the air volume of each airway generation within the lung. It is a generic model that can be used as a powerful tool in interpreting images of aerosol deposition. The model divides the lung volume into 10 concentric shells, and specifies the volume of each airway generation in each shell based on a statistical analysis of morphometric data available in the literature. In this study, an updated version of the conceptual model, called the Hybrid Conceptual Model (HCM), is introduced. This model incorporates individual morphometric data from upper bronchial airways (generations 0-5) available from High Resolution Computed Tomography (HRCT). The HCM has been tested on one 27-year-old healthy male volunteer, on which magnetic resonance imaging (MRI) and HRCT scans of the thorax have been performed. Four major changes have been introduced in the HCM; (1) the incorporation of in vivo data, (2) a better distribution of airway volume within each shell, (3) the adoption of more accurate morphometric assumptions, and (4) the incorporation of the spatial definition of the segmental divisions of the lung. The resulting model was shown to compare very well to past literatu...Continue Reading

References

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Citations

Mar 23, 2013·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Joy ConwayTom Havelock
Feb 28, 2013·Therapeutic Delivery·Gabriela Apiou-SbirleaAnthony Hickey
May 14, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michael Yifei YangHak-Kim Chan
Dec 21, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·John FlemingGabriela Apiou-Sbirlea
Feb 9, 2012·Advanced Drug Delivery Reviews·Joy Conway
Apr 9, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Spyridon MontesantosGeorges Caillibotte
Jun 1, 2013·Journal of Biomechanical Engineering·Ross L WalengaP Worth Longest

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