A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms

Journal of Theoretical Biology
Orestis MalaspinasBastien Chopard


We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.


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Related Concepts

Mycotic Aneurysm, Intracranial
In Silico
Poly(A) Tail
Stress, Mechanical
Human Umbilical Vein Endothelial Cells
Space-Time Geography
Anatomical Space Structure

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