A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms

Journal of Theoretical Biology
Orestis MalaspinasBastien Chopard

Abstract

We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.

References

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Citations

Apr 3, 2016·Medical Physics·Yan WangGuy Courbebaisse
Nov 4, 2016·Journal of the Royal Society, Interface·Claudia MenichiniXiao Yun Xu
Oct 27, 2016·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Thomas PeachYiannis Ventikos
May 11, 2017·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ali Sarrami-ForoushaniAlejandro F Frangi
Oct 12, 2016·Journal of Biomechanical Engineering·Ronak DholakiaBaruch B Lieber
May 10, 2017·Royal Society Open Science·Bastien ChopardKarim Zouaoui Boudjeltia
Jun 27, 2020·Scientific Reports·Kamil Jerzy ChodzyǹskiKarim Zouaoui Boudjeltia
Sep 28, 2018·Journal of the Royal Society, Interface·B CzajaA G Hoekstra
Dec 2, 2020·The International Journal of Artificial Organs·Wei-Feng DaiGuang-Mao Liu

Related Concepts

Mycotic Aneurysm, Intracranial
In Silico
Poly(A) Tail
Stress, Mechanical
Thrombus
Hemorheology
Human Umbilical Vein Endothelial Cells
Space-Time Geography
Thrombus
Anatomical Space Structure

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