PMID: 7545425Aug 1, 1995Paper

A specific chromosome abnormality of t(4;12)(q11-12;p13) in CD7+ acute leukaemia

British Journal of Haematology
H HaradaN Kamada

Abstract

Three cases of acute leukaemia with t(4;12) (q11-12;p13) karyotypic abnormalities were analysed. They had the following common clinical and biological characteristics: (1) dysplasia of three haemopoietic lineages: (2) absent or low myeloperoxidase activity: and (3) retention of platelets in the peripheral blood and megakaryocytes in the bone marrow. There were increased numbers of basophils in the bone marrow and peripheral blood in two of the cases. In all, the blast cells displayed the unique immunophenotype CD7+CD13+CD34+HLA-DR+. The blasts analysed in one case expressed c-kit on the membrane surface. These findings suggest that the t(4;12) (q11-12;p13) abnormality is associated with a particular type of acute leukaemia, one in which the morphology and immunophenotype suggest that the translocation may have occurred at an early stage of haemopoiesis.

Citations

Mar 1, 1997·Leukemia & Lymphoma·H HaradaN Kamada
Mar 31, 2015·British Journal of Haematology·Danika Di GiacomoCristina Mecucci
Jul 7, 2016·Blood Research·Kyung-Hee KimJi-Hun Jeong
Sep 8, 2021·Journal of Cellular and Molecular Medicine·Vincent ParinetUNKNOWN on behalf the FILO (French Innovative Leukemia Organization), GFCH (Groupe Francophone de Cytogénétique Hématologique) group

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