A specific diplotype defined by PPP1R13L rs1970764, CD3EAP rs967591 and ERCC1 rs11615 and lung cancer risk in a Chinese population

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Jiaoyang YinXinxin Li

Abstract

Haplotypes defined by multiple loci may be more precise and useful than genotypes in providing risk estimates for particular cancers. Diplotype is defined as a specific combination of two haplotypes. A Chinese case-control analysis comprising 370 cases and 388 controls was conducted to evaluate the effects of the high-risk diplotype predefined as PPP1R13L rs1970764(AA)-CD3EAP rs967591(GG)-ERCC1 rs11615(AA) among Caucasians and three SNPs alone or other haplotypes combined for lung cancer risk. Both the variant G-allele of PPP1R13L rs1970764 and the variant A-allele of CD3EAP rs967591 were significantly over-represented among cases (P=0.03 and P=0.002, respectively). The variant GG-homozygotes of PPP1R13L rs1970764 had increased risk [GG versus AA: adjusted OR (95% CI)=1.30 (1.04-1.62), P=0.02]. The carriers of variant A-allele of CD3EAP rs967591 also presented increased risk [AA versus GG: adjusted OR (95% CI)=1.40 (1.12-1.75), P=0.004; AG versus GG: adjusted OR (95% CI)=1.47 (1.05-2.07), P=0.03 and AG+AA versus GG: adjusted OR (95% CI)=1.26 (1.07-1.48), P=0.005]. Interaction between CD3EAP rs967591 and smoking duration was observed (P=0.003). Only haplotype 1 (the common haplotype) defined as PPP1R13L rs1970764(G)-CD3EAP rs967...Continue Reading

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Citations

Aug 6, 2013·Genetic Testing and Molecular Biomarkers·Zecheng YangHuixiang Li
Feb 25, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaoyu LiBo Bai
Nov 28, 2012·Journal of Cancer Research and Clinical Oncology·Yee Soo ChaeWon Kee Lee
Oct 11, 2013·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Amal A FaragAly A Farag
Nov 14, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiaoyang YinYegang Ma
Aug 22, 2018·Current Medical Science·Jiao-Yang YinZhen-Xiang Sun
Jun 19, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hyo-Sung JeonJae Yong Park

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