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A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH

Proceedings of the National Academy of Sciences of the United States of America

Aug 1, 1984

J PouysségurS Paris

PMID: 6087349

Abstract

A H+-suicide technique based on the reversibility of Na+/H+ antiport was developed for the selection of mutants deficient in this membrane-bound activity. The strategy was to use the Na+/H+ antiporter as a H+-vector killing device. Chinese hamster lung fibroblasts (CCL39) were loaded wi...read more

Mentioned in this Paper

Chinese Hamster
Choline
Antiporter Activity
Specimen Type - Fibroblasts
SLC9A1 gene
Lung
Sodium-Hydrogen Antiporter
Protoplasm
Hamsters
Acidification - ActCode
45
Paper Details
References
  • References20
  • Citations269
12
  • References20
  • Citations269
12345...

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A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH

Proceedings of the National Academy of Sciences of the United States of America

Aug 1, 1984

J PouysségurS Paris

PMID: 6087349

DOI:

Abstract

A H+-suicide technique based on the reversibility of Na+/H+ antiport was developed for the selection of mutants deficient in this membrane-bound activity. The strategy was to use the Na+/H+ antiporter as a H+-vector killing device. Chinese hamster lung fibroblasts (CCL39) were loaded wi...read more

Mentioned in this Paper

Chinese Hamster
Choline
Antiporter Activity
Specimen Type - Fibroblasts
SLC9A1 gene
Lung
Sodium-Hydrogen Antiporter
Protoplasm
Hamsters
Acidification - ActCode
45

Feeds With Similar Papers

Gut & Phospholipid Metabolism

Phospholipids are the major component of cell membranes. This feed focuses on the role of gut microorganisms in phospholipid metabolism.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization(opens in new tab)

Proceedings of the National Academy of Sciences of the United States of AmericaDecember 1, 1982
S Schuldiner, E Rozengurt
Paper Details
References
  • References20
  • Citations269
12
  • References20
  • Citations269
12345...

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