PMID: 66571Apr 9, 1977Paper

A specific orally active inhibitor of angiotensin-converting enzyme in man

Lancet
R K FergusonD N McKinstry

Abstract

An orally active inhibitor of the angiotensin-converting enzyme, SQ 14,225 (D-2-methyl-3-mercaptopropanoly-L-proline), was administered to fourteen normal male volunteers to evaluate its safety and efficacy in inhibiting pressor responses to exogenous angiotensin I. SQ 14,225 produced significant blockade within 15 min of oral administration. The magnitude and duration of inhibition were dose-related. After a dose of 20 mg, complete blockade was observed for more than 2 h and partial inhibition for over 4 h. There was no effect on pressor responses to angiotensin II. SQ 14,225 promises to provide a new approach to the diagnosis and treatment of disorders involving over-activity of the renin-angiotensin system.

Citations

Apr 1, 1991·Journal of Clinical Pharmacology·M A BaezD J Weidler
Jan 1, 1991·European Journal of Clinical Pharmacology·I F GowC R Edwards
Jan 1, 1984·European Journal of Clinical Pharmacology·M D SchallerH R Brunner
Jan 1, 1985·European Journal of Clinical Pharmacology·M D SchallerH R Brunner
Jan 1, 1983·European Journal of Clinical Pharmacology·J BiollazH R Brunner
Jan 1, 1981·European Journal of Clinical Pharmacology·P LijnenA Amery
Jan 1, 1985·European Journal of Clinical Pharmacology·R J FruncilloR K Ferguson
Mar 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·J P BussienP Hajdu
Jan 15, 1981·Klinische Wochenschrift·A StuderW Vetter
Oct 21, 1983·Pharmaceutisch Weekblad. Scientific Edition·P A Van ZwietenP B Timmermans
Apr 17, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Michael Bader, Detlev Ganten
Dec 1, 2011·Nanoscale Research Letters·Suguna Lakshmi MaduraiBoreddy Sr Reddy
Oct 1, 1987·American Heart Journal·B N Prichard, B Tomlinson
Nov 1, 1980·The American Journal of Medicine·H R Brunner, H Gavras
Jul 15, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·F M DuncanC R Edwards
Dec 1, 1977·European Journal of Pharmacology·V S MurthyR R Vollmer
Sep 1, 1978·European Journal of Pharmacology·R R VollmerV S Murthy
Jun 1, 1981·Journal of Pharmacological Methods·I L NatoffA T Patel
Jan 1, 1986·The Journal of Emergency Medicine·M S Catapano, J A Marx
Oct 20, 1979·Lancet·A B Atkinson, J I Robertson
Feb 29, 2000·International Journal of Pharmaceutics·A O Nur, J S Zhang
Jan 1, 1983·Journal of the American College of Cardiology·E D Frohlich
Nov 1, 1983·Journal of the American College of Cardiology·M Packer
Mar 16, 1978·The New England Journal of Medicine·R ReE Haber
May 4, 1978·The New England Journal of Medicine·H GavrasD N McKinstry
Jun 21, 1979·The New England Journal of Medicine·J A Lopez-OvejeroJ H Laragh
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R L SofferC Gloff
Jan 1, 1979·British Journal of Clinical Pharmacology·H R BrunnerI Gavras
Jan 1, 1979·British Journal of Clinical Pharmacology·Z P HorovitzR E Panasevich
Feb 1, 1988·Clinical and Experimental Pharmacology & Physiology·G K MoldenhauerT O Morgan
Mar 1, 1982·Archives of Disease in Childhood·W GriswoldS Mendoza
Feb 1, 1989·Archives of Disease in Childhood·C E Daman WillemsM J Dillon
Sep 23, 1978·British Medical Journal·M J VandenburgE J Rucinska
Nov 3, 1979·British Medical Journal·G A MacGregorJ C Jones

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