PMID: 2116539Apr 1, 1990Paper

A specific protein inhibiting membrane permeation of chloramphenicol in Pseudomonas aeruginosa

The Japanese journal of antibiotics
K O'HaraM Kono

Abstract

A specific protein (MW 18,000) was found using chloramphenicol (CP) base-affinity chromatography of periplasmic-space proteins obtained from an impermeability-type CP-resistant Pseudomonas aeruginosa harboring plasmid kR102. Membrane reconstitution experiments using a liposome system appeared to indicate that the permeability of CP was inhibited by the specific protein.

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