A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling

Nature Genetics
Hao DingAndras Nagy

Abstract

PDGF-C is a member of the platelet-derived growth factor (PDGF) family, which signals through PDGF receptor (PDGFR) alphaalpha and alphabeta dimers. Here we show that Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos. Pdgfc(-/-) Pdgfa(-/-) embryos developed a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme, spina bifida and skeletal and vascular defects. Complete loss of function of both ligands, therefore, phenocopied the loss of PDGFR-alpha function, suggesting that both PDGF-A and PDGF-C signal through PDGFR-alpha to regulate the development of craniofacial structures, the neural tube and mesodermal organs. Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated.

References

Dec 1, 1995·Nature Genetics·G ProetzelT Doetschman
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A NagyJ C Roder
Mar 31, 2000·Nature Genetics·M J van den BoogaardH K van Amstel
Feb 7, 2001·Developmental Biology·C Martínez-AlvarezM W Ferguson
May 12, 2000·Nature Cell Biology·X LiU Eriksson
Apr 12, 2001·The Journal of Biological Chemistry·D G GilbertsonC E Hart
Jun 1, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C BetsholtzP Lindahl
Dec 18, 2001·Mechanisms of Development·Karin AaseUlf Eriksson
May 29, 2002·Clinical Genetics·J C Murray
Jun 28, 2002·American Journal of Human Genetics·Mary L MarazitaYou-e Liu
Sep 10, 2002·Nature Genetics·Shinji KondoJeffrey C Murray
Sep 4, 2003·Development·Renée V Hoch, Philippe Soriano

❮ Previous
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Citations

May 21, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tammo OstendorfJürgen Floege
May 30, 2013·Trends in Molecular Medicine·Chunsik LeeXuri Li
Dec 19, 2008·European Journal of Human Genetics : EJHG·Sun J ChoiThomas C Hart
Apr 5, 2012·European Journal of Human Genetics : EJHG·Sawitree RattanasophaVorasuk Shotelersuk
Feb 12, 2008·Nature Genetics·Johann K EberhartJohn H Postlethwait
Sep 15, 2010·Nature Reviews. Nephrology·Peter BoorJürgen Floege
Jun 14, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M E LacoutureJ Guitart
Jan 10, 2012·Human Molecular Genetics·Alyson AsheCarol Wicking
Feb 15, 2008·Nucleic Acids Research·Estella Sanchez-GuerreroLevon M Khachigian
Aug 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter Boor, Jürgen Floege
Nov 30, 2011·Current Opinion in Nephrology and Hypertension·Taizo NakagawaMasakiyo Sasahara
May 17, 2008·Genes & Development·Johanna AndraeChrister Betsholtz
Aug 2, 2006·Molecular and Cellular Biology·Tae-Ju ParkTom Curran
Nov 11, 2011·BMC Developmental Biology·Minoru KawakamiKen-Ichi Yamamura
Oct 3, 2013·PLoS Genetics·Fenglei He, Philippe Soriano
May 7, 2011·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Fedik RahimovJeffrey C Murray
Jan 11, 2008·Journal of the American Society of Nephrology : JASN·Frank EitnerTammo Ostendorf
Sep 2, 2011·Chinese Journal of Cancer·Kun-Wei LiuShi-Yuan Cheng
Jun 25, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Carl-Henrik Heldin
May 30, 2013·Indian Journal of Human Genetics·Laura C BarrittSonia M Rocha-Sanchez
Feb 5, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter BoorJürgen Floege
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xu HouXuri Li
Apr 9, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yujuan WangChi-Chao Chan
Apr 8, 2014·Cytokine & Growth Factor Reviews·Jean-Baptiste Demoulin, Ahmed Essaghir
Jan 17, 2015·Iranian Red Crescent Medical Journal·Sima TavakolinejadDaryoush Hamidi Alamdari
Oct 5, 2011·Nutrition Reviews·Mignon M G AckermansJohannes W Von den Hoff
Dec 22, 2015·Acta Neuropathologica·Sebastian A LewandowskiUlf Eriksson
Mar 15, 2012·Alcoholism, Clinical and Experimental Research·Chris DowningThomas E Johnson
Apr 19, 2012·Upsala Journal of Medical Sciences·Inga NazarenkoMonica Nistér
Feb 22, 2012·Upsala Journal of Medical Sciences·Lena Claesson-Welsh
Jan 5, 2005·The Journal of Clinical Investigation·Xuri LiPeter Carmeliet
Oct 4, 2011·Organogenesis·Benjamin LeviDerrick C Wan

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