A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory

Neuroscience
Bengi Altinbilek, D Manahan-Vaughan

Abstract

Activity-dependent and sustained alterations in synaptic efficacy are widely regarded as the cellular correlates underlying learning and memory. Metabotropic glutamate receptors (mGluRs) are intrinsically involved in both hippocampal synaptic plasticity and spatial learning. Group II mGluRs are required for persistent hippocampal long-term depression (LTD), but are not required for long-term potentiation (LTP) in the hippocampal CA1 region in vivo. The role of these receptors in spatial learning, and in synaptic plasticity in the dentate gyrus in vivo has not yet been the subject of close scrutiny. We investigated the effects of group II mGluR antagonism on LTP and LTD in the adult rat, at medial perforant path-dentate gyrus synapses, and on spatial learning in the eight-arm radial maze. Daily application of the group 2 mGluR antagonist (2S)-alpha-ethylglutamic acid (EGLU) resulted in impairment of long-term (reference) memory with effects becoming apparent 6 days after training and drug-treatment began. Short-term (working) memory was unaffected throughout the 10-day study. Acute injection of EGLU did not affect either LTD or LTP in the dentate gyrus in vivo. Following six daily applications of EGLU a clear impairment of LTD b...Continue Reading

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Citations

Mar 5, 2013·Nature Neuroscience·Joshua LevitzEhud Y Isacoff
Nov 3, 2010·Neuropharmacology·F NicolettiJ P Pin
Nov 26, 2008·Neuroscience·S DavangerO P Ottersen
Jun 10, 2014·Hippocampus·Sijie Zhang, Denise Manahan-Vaughan
Jun 30, 2012·Neuropharmacology·Sreedeep Mukherjee, Denise Manahan-Vaughan
Feb 26, 2019·Frontiers in Molecular Neuroscience·Rosalia CrupiSalvatore Cuzzocrea
Mar 26, 2021·Oxidative Medicine and Cellular Longevity·Ewelina Bratek-GerejElzbieta Salinska
Jul 6, 2021·Frontiers in Cellular Neuroscience·Salma E Reyes-García, Martha L Escobar

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