A Specifically Designed Multispecies Probiotic Supplement Relieves Seasonal Allergic Rhinitis Symptoms

The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
Annabelle M WattsNicholas P West

Abstract

Probiotics are purported to reduce symptoms of allergic rhinitis. This study sought to determine the proportion of participants with an improvement in the mini Rhinoconjunctivitis Quality of Life Questionnaire (mRQLQ) in response to a multispecies probiotic supplement with a Simon Two-Stage design. This study was based on a Simon Two-Stage Design for p1-p0 = 0.18 to account for seasonal variation in symptoms. Under this design, ≥10 patients are required to exhibit an improvement in quality-of-life scores to determine that there was sufficient activity for the supplement to be considered effective. Participants consumed a probiotic supplement (Ecologic® AllergyCare; probiotik®pur) twice daily for 8 weeks. The primary outcome measure was based on a change in mRQLQ scores following supplementation. Secondary outcomes include assessment of change in symptoms and medication usage with a twice-weekly symptom and medication diary, nasal congestion by rhinomanometry, and total serum Immunoglobulin E (IgE) and specific IgE for Bermuda grass. A total of 40 participants completed the study. A total of 25 participants (63%, 49-76%, p < 0.001; mean, 95% confidence interval, p-value) out of 40 participants had a clinically meaningful respons...Continue Reading

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Citations

Oct 29, 2019·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Michelle Jalousie KommersCarlos Alexandre Fett
Jan 28, 2019·Applied Microbiology and Biotechnology·Sinead T MorrinRita M Hickey
Aug 9, 2020·Allergologia et immunopathologia·M EslamiB Yousefi
Jun 9, 2020·Complementary Therapies in Medicine·Janice PellowElizabeth M Solomon

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ESR

Software Mentioned

SPSS Statistics

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