PMID: 15357002Sep 11, 2004Paper

A sphingolipid and tyrosinase inhibitors from the fruiting body of Phellinus linteus

Archives of Pharmacal Research
Hye Sook KangJae Sue Choi

Abstract

This paper for the first time reports the isolation of 5 compounds from Phellinus linteus. A sphingolipid (1) and two tyrosinase inhibitory compounds (2, 3) along with two carboxylic acids (4, 5), were isolated from the fruiting body of Phellinus linteus (Berk & Curt) Aoshima. The structure of compound 1 was identified as 1-omicron-beta-D-glucopyranosyl-(2S, 3R, 4E, 8E)-2-[(2R)-2-hydroxyhexadecanoylamino]-9-methyl-4,8-octadecadiene-1,3-diol, known as cerebroside B, based on spectroscopic methods such as 1 D and 2D NMR as well as by acid hydrolysis. Compounds 2 -5 were identified as protocatechualdehyde (2), 5-hydroxymethyl-2-furaldehyde (HMF) (3), succinic acid (4), and fumaric acid (5) based on the spectroscopic evidence. Compounds 2 and 3 inhibited the oxidation of L-tyrosine catalyzed by mushroom tyrosinase with an IC50 of 0.40 and 90.8 microg/mL, respectively. The inhibitory kinetics, which were analyzed by the Lineweaver-Burk plots, were found to be competitive and noncompetitive inhibitors with a Ki of 1.1 microM and 1.4 mM, respectively.

References

Aug 5, 1966·Journal of the American Chemical Society·R C Gaver, C C Sweeley
Oct 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R J UlbrichtJ A Thomas
May 1, 1994·The Journal of Nutrition·D L DillehayA H Merrill
Jul 1, 1993·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K WatanabeY Mori
Mar 1, 1996·Journal of Natural Products·J H JungS S Kang
May 1, 1996·International Journal of Immunopharmacology·H M KimI D Yoo
Mar 1, 1997·Journal of Natural Products·S Y KimH S Lee
Apr 1, 1997·Brain Research. Molecular Brain Research·Y XuK E Vrana
Jul 8, 1999·The Journal of Nutrition·H VesperA H Merrill
Jul 30, 1999·Journal of Natural Products·S S KangY H Kim
Aug 10, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C JanzowskiG Eisenbrand
Mar 20, 2001·Chemical & Pharmaceutical Bulletin·S S KangH W Chang
Aug 3, 2001·Journal of Ethnopharmacology·Y H Shon, K S Nam
Aug 18, 2001·Journal of Nutritional Science and Vitaminology·H KikuzakiN Nakatani
Sep 29, 2001·Journal of Natural Products·J M YueH D Sun
Nov 13, 2001·American Journal of Clinical Dermatology·A Pérez-BernalF Camacho
Feb 28, 2002·The Journal of Biological Chemistry·Yeon Mi KimYoungsoo Kim
Jul 26, 2002·Journal of Agricultural and Food Chemistry·Shengmin SangChi-Tang Ho
Feb 20, 2003·Journal of Agricultural and Food Chemistry·Ohad NeryaSnait Tamir

❮ Previous
Next ❯

Citations

Mar 3, 2007·Archives of Pharmacal Research·Chun-Whan ChoiJae Sue Choi
Jun 6, 2009·Journal of Natural Medicines·Toshihiro MurataFumihiko Yoshizaki
Apr 23, 2011·Journal of Nutritional Science and Vitaminology·Zhi-Qiang ChangSeung-Chun Park
Jul 8, 2009·International Journal of Molecular Sciences·Te-Sheng Chang
Jan 8, 2010·International Journal of Molecular Sciences·Nico SmitStan Pavel
Mar 17, 2007·ChemMedChem·Yovani Marrero-PonceRichard Rotondo
May 18, 2016·Journal of Natural Medicines·Fenqin ZhaoGuang Han
Aug 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huaizhi LiXiao Wang
Nov 24, 2007·Biotechnology Journal·Chitrangada AcharyaSubhas C Kundu
Apr 2, 2008·Biological & Pharmaceutical Bulletin·Yeon Sil LeeSoon Sung Lim
May 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wenhua ChenLingchuan Xu
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Samaneh ZolghadriAli Akbar Saboury
May 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Verena Spiegler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.