A sphingolipid mechanism for behavioral extinction

Journal of Neurochemistry
Joseph P HustonChristian P Müller

Abstract

Reward-dependent instrumental behavior must continuously be re-adjusted according to environmental conditions. Failure to adapt to changes in reward contingencies may incur psychiatric disorders like anxiety and depression. When an expected reward is omitted, behavior undergoes extinction. While extinction involves active re-learning, it is also accompanied by emotional behaviors indicative of frustration, anxiety, and despair (extinction-induced depression). Here, we report evidence for a sphingolipid mechanism in the extinction of behavior. Rapid extinction, indicating efficient re-learning, coincided with a decrease in the activity of the enzyme acid sphingomyelinase (ASM), which catalyzes turnover of sphingomyelin to ceramide, in the dorsal hippocampus of rats. The stronger the decline in ASM activity, the more rapid was the extinction. Sphingolipid-focused lipidomic analysis showed that this results in a decline of local ceramide species in the dorsal hippocampus. Ceramides shape the fluidity of lipid rafts in synaptic membranes and by that way can control neural plasticity. We also found that aging modifies activity of enzymes and ceramide levels in selective brain regions. Aging also changed how the chronic treatment wit...Continue Reading

References

Jul 1, 1995·Acta Paediatrica·A LekmanL Svennerholm
Jan 1, 1997·Annual Review of Psychology·R C Kessler
Oct 6, 1997·Science·R M Nesse, K C Berridge
Jul 1, 1997·International Clinical Psychopharmacology·P Willner
Jan 19, 1999·Annual Review of Cell and Developmental Biology·D A Brown, E London
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
Jul 27, 2000·Journal of Cellular Physiology·R N KolesnickA Alonso
Apr 17, 2001·The Behavioral and Brain Sciences·J A Nevin, R C Grace
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·K Simons, D Toomre
Jun 27, 2002·Journal of the Experimental Analysis of Behavior·Richard L ShullJulie A Grimes
Aug 26, 2003·Brain, Behavior and Evolution·Mauricio R Papini
Apr 12, 2005·Journal of Affective Disorders·Paul WillnerSpilios Argyropoulos
Oct 26, 2005·Journal of Neural Transmission·J KornhuberE Gulbins
Nov 25, 2005·Current Drug Delivery·Tushar K VyasAmbikanandan Misra
Dec 13, 2005·Neurobiology of Learning and Memory·Angela D MiracleCara L Wellman
May 26, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alicia IzquierdoAndrew Holmes
Jun 15, 2007·Cellular and Molecular Life Sciences : CMLS·S Lahiri, A H Futerman
Aug 25, 2007·Annual Review of Clinical Psychology·Constance Hammen
Sep 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregory J Quirk, Devin Mueller
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Gerrit van MeerGerald W Feigenson
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
Aug 14, 2008·Journal of Neurochemistry·Ilse Delint-RamírezFederico Bermudez-Rattoni
Mar 31, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Lucia A RuoccoAdolfo G Sadile
Sep 8, 2009·Biochimica Et Biophysica Acta·Jacques Fantini, Francisco J Barrantes
Sep 15, 2009·Acta Pharmacologica Sinica·Santosh J SacketDong-Soon Im
Oct 6, 2009·Current Protocols in Neuroscience·Shannon L Gourley, Jane R Taylor
Mar 4, 2010·Experimental Gerontology·Nataliya A Babenko, Yaroslava A Semenova
Mar 5, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caroline NothdurfterRainer Rupprecht
Jul 16, 2010·Journal of Neuroscience Research·Nino TabatadzeNorman J Haughey
Mar 8, 2011·Psychoneuroendocrinology·Lars Schwabe, Oliver T Wolf
Jan 19, 2012·Neurochemical Research·Cara-Lynne SchengrundJeanette C Ramer
Mar 20, 2012·Behavioural Processes·John A Nevin
Apr 28, 2012·The Journal of Biological Chemistry·Patricia CarrascoNúria Casals
Jul 24, 2012·Neuropharmacology·Ana M SebastiãoJoaquim A Ribeiro

❮ Previous
Next ❯

Citations

Mar 19, 2016·Journal of Neurochemistry·Sandro Sonnino, Alessandro Prinetti
Oct 25, 2016·Hormones and Behavior·Joseph P HustonBianca Topic
Jan 28, 2017·British Journal of Pharmacology·Mercedes Garcia-GilElisabetta Meacci
Jan 13, 2018·Journal of Neural Transmission·Liubov S KalinichenkoChristian P Müller
Mar 12, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mark J McVeyWolfgang M Kuebler
Jun 17, 2018·Biological Chemistry·Nadine BeckmannAlexander Carpinteiro
Jun 16, 2019·Journal of Clinical Medicine·Christiane MühleJohannes Kornhuber
May 15, 2020·Journal of Psychopharmacology·Estabraq JaddoaTyra Zetterström
Sep 17, 2020·Pharmacological Reports : PR·Liubov S KalinichenkoChristian P Müller
Aug 27, 2017·Neurotoxicity Research·Justyna BrodowiczMalgorzata Filip
Apr 28, 2019·Translational Psychiatry·André Miguel MirandaTiago Gil Oliveira
Oct 13, 2020·Cerebral Cortex·Liubov S KalinichenkoChristian P Müller
Nov 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Paola TogniniPaolo Sassone-Corsi
Jul 21, 2021·Translational Psychiatry·Katarina IlicSvjetlana Kalanj-Bognar
Jul 31, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·B DrukarchM M M Wilhelmus
Aug 28, 2021·International Journal of Molecular Sciences·Bernadette Breiden, Konrad Sandhoff
Sep 30, 2021·Molecular Psychiatry·Liubov S KalinichenkoChristian P Müller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.