A spiking neural network model of the midbrain superior colliculus that generates saccadic motor commands

Biological cybernetics
Bahadir Kasap, A J Van Opstal

Abstract

Single-unit recordings suggest that the midbrain superior colliculus (SC) acts as an optimal controller for saccadic gaze shifts. The SC is proposed to be the site within the visuomotor system where the nonlinear spatial-to-temporal transformation is carried out: the population encodes the intended saccade vector by its location in the motor map (spatial), and its trajectory and velocity by the distribution of firing rates (temporal). The neurons' burst profiles vary systematically with their anatomical positions and intended saccade vectors, to account for the nonlinear main-sequence kinematics of saccades. Yet, the underlying collicular mechanisms that could result in these firing patterns are inaccessible to current neurobiological techniques. Here, we propose a simple spiking neural network model that reproduces the spike trains of saccade-related cells in the intermediate and deep SC layers during saccades. The model assumes that SC neurons have distinct biophysical properties for spike generation that depend on their anatomical position in combination with a center-surround lateral connectivity. Both factors are needed to account for the observed firing patterns. Our model offers a basis for neuronal algorithms for spatio...Continue Reading

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Citations

Jun 30, 2018·Prenatal Diagnosis·Fergus ScottAndrew McLennan
Nov 1, 2018·Journal of Neurophysiology·Laurent GoffartJean-Charles Quinton
Apr 13, 2019·PLoS Computational Biology·Bahadir Kasap, A John van Opstal
Apr 21, 2018·Expert Review of Molecular Diagnostics·Malgorzata I SrebniakDiane Van Opstal
Feb 1, 2018·Journal of Neurophysiology·Bahadir Kasap, A John van Opstal
Jan 1, 2018·Frontiers in Applied Mathematics and Statistics·Bahadir Kasap, A John van Opstal
Dec 31, 2020·Journal of Neurophysiology·Guus C van BentumA John van Opstal

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