A spindle cell predominant pancreatic solid-pseudopapillary tumor.

Yonsei Medical Journal
Jai Hyang Go

Abstract

A hitherto unrecognized variant of solid-pseudopapillary tumor (SPT) of the pancreas is reported. The tumor presented in the pancreatic tail of a 44-year-old female patient. It was a well-defined, solid nodule measuring 25 mm in diameter, with homogenous tan gray cut surface. Histologically, the neoplasm was mostly composed of sheets of spindle cells. No cellular atypia and mitosis was identified. The periphery of the tumor showed typical feature of SPT. Immunohistochemically, the tumor cells were positive for vimentin, CD10, CD56, beta-catenin, and alpha1-antichymotrypsin, but negative for cytokeratin, chromogranin, synaptophysin and S-100 protein. Ultrastructurally, the tumor showed a few acinar spaces with microvilli between tumor cells. This case is peculiar in that the tumor did not show gross cystic change and predominantly consists of spindle shaped tumor cells, so may cause difficult diagnostic problem.

References

May 23, 2002·The American Journal of Surgical Pathology·Yukichi TanakaYukio Nakatani
Mar 3, 2004·Journal of Surgical Oncology·Atul K MadanAml Raafat
Jun 1, 2005·Journal of the American College of Surgeons·Theodossios Papavramidis, Spiros Papavramidis

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Citations

Dec 5, 2009·Pancreas·Mona A El-BahrawyGordon W H Stamp
Apr 12, 2011·Gastroenterología y hepatología·Laura Carreño ToroVerónica Sanhueza Linares
Feb 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexander ZuriarrainAshwani Rajput

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Methods Mentioned

BETA
pancreatectomy

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