A spirohydantoin derivative of oxymorphone: an agonist with delayed antagonist activity.

Pharmacology, Biochemistry, and Behavior
G J AlexanderH M Wisniewski

Abstract

We have synthesized a novel derivative of oxymorphone, oxymorphone-6 alpha-spirohydantoin. The derivative was less toxic in mice than the parent compound and it showed a significant anticonvulsive activity. It exerted agonist effects in doses lower than those of morphine and its agonist effects were longer lasting. Furthermore, both oxymorphone and the 6-spirohydantoin showed definite antagonist properties 48 hr later: they prevented analgesic effects of morphine. The antagonist effects of the derivative persisted for a week.

References

Jun 1, 1979·Pharmacology, Biochemistry, and Behavior·K W LiebermanP Stokes
Aug 10, 1987·Life Sciences·S GalettaG W Pasternak
Jan 1, 1986·Annals of the New York Academy of Sciences·B R Komisaruk, B Whipple
Dec 1, 1986·Neurochemical Research·N Chatterjie, G J Alexander
Mar 1, 1984·Cellular and Molecular Neurobiology·G S LingG W Pasternak
Sep 1, 1983·Neuropharmacology·N Chatterjie, G J Alexander

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Citations

Dec 1, 1989·Neurochemical Research·G J Alexander, N Chatterjie

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