PMID: 9531542May 9, 1998Paper

A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth

Genes & Development
L ShermanP Herrlich

Abstract

Signals from the apical ectodermal ridge (AER) of the developing vertebrate limb, including fibroblast growth factor-8 (FGF-8), can maintain limb mesenchymal cells in a proliferative state. We report here that a specific CD44 splice variant is crucial for the proliferation of these mesenchymal cells. Epitopes carried by this variant colocalize temporally and spatially with FGF-8 in the AER throughout early limb development. A splice variant containing the same sequences expressed on model cells binds both FGF-4 and FGF-8 and stimulates mesenchymal cells in vitro. When applied to the AER, an antibody against a specific CD44 epitope blocks FGF presentation and inhibits limb outgrowth. Therefore, CD44 is necessary for limb development and functions in a novel growth factor presentation mechanism likely relevant in other physiological and pathological situations where a cell surface protein presents a signaling molecule to a neighboring cell.

References

Aug 1, 1992·The Journal of Cell Biology·L ThomasI Stamenkovic
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G R ScreatonJ I Bell
May 1, 1992·Developmental Biology·J S Geduspan, M Solursh
Feb 1, 1992·The Journal of Cell Biology·S Jalkanen, M Jalkanen
Oct 1, 1991·The Journal of Experimental Medicine·M S SyI Stamenkovic
Nov 15, 1990·International Journal of Cancer. Journal International Du Cancer·S ReberM Zöller
Jan 1, 1989·The Journal of Experimental Zoology·N WanekS V Bryant
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·I VlodavskyM Klagsbrun
Sep 1, 1986·Journal of Cellular Physiology·D Gospodarowicz, J Cheng
Dec 1, 1985·Developmental Biology·C B Knudson, B P Toole
Aug 24, 1973·Nature·D SummerbellL Wolpert
Apr 1, 1983·Teratology·T R Strecker, T D Stephens
Oct 1, 1993·PCR Methods and Applications·D H van WeeringJ L Bos
Feb 8, 1995·International Journal of Cancer. Journal International Du Cancer·P DallH Ponta
Aug 1, 1995·Current Opinion in Genetics & Development·T P Yamaguchi, J Rossant
Aug 1, 1995·The Journal of Cell Biology·T OchiyaM Terada
Oct 28, 1994·Biochemical and Biophysical Research Communications·H OhuchiS Noji
Nov 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M P SavageJ F Fallon

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Citations

Jan 25, 2011·Annals of Hematology·Magdalena Katharina HertweckKarl-Anton Kreuzer
Sep 12, 2007·Journal of Clinical Immunology·Ponlatham ChaiyaritMantharop Chaimusig
Oct 16, 2003·Trends in Biochemical Sciences·Andrea Bertotti, Paolo M Comoglio
Nov 14, 2000·The American Journal of Pathology·V J WielengaS T Pals
Dec 22, 1999·Biochemical Pharmacology·P Herrlich, F D Böhmer
Jun 23, 1999·Experimental Hematology·S GhaffariC Eaves
Feb 6, 2002·Matrix Biology : Journal of the International Society for Matrix Biology·Kathleen T Rousche, Cheryl B Knudson
Jul 9, 2010·The Journal of Biological Chemistry·N Helge MeyerMichael Sattler
Mar 5, 2011·The Journal of Biological Chemistry·Thorsten JungMargot Zöller
Oct 27, 2006·Molecular Biology of the Cell·Véronique Orian-RousseauHelmut Ponta
Aug 3, 2001·The EMBO Journal·S Weg-RemersH König
Sep 16, 2011·Cold Spring Harbor Perspectives in Biology·Pengfei LuZena Werb
Jul 5, 2006·Genes & Development·Chonghui ChengPhillip A Sharp
Dec 5, 2002·Genes & Development·Véronique Orian-RousseauHelmut Ponta
Oct 10, 2007·Molecular and Cellular Biology·Alexandra MatzkeVéronique Orian-Rousseau
Dec 16, 2005·Molecular and Cellular Biology·Chonghui Cheng, Phillip A Sharp
Nov 1, 2001·Annual Review of Cell and Developmental Biology·J Capdevila, J C Izpisúa Belmonte
Aug 6, 2009·BMC Bioinformatics·Yiyuan SheHui Wang
Aug 20, 2008·BMC Research Notes·Elena VelaMarcos Isamat
Jun 8, 2001·Biochemical and Biophysical Research Communications·M M Fiore
Aug 17, 1999·Current Opinion in Genetics & Development·C Tickle, M Altabef
Aug 28, 2003·Médecine sciences : M/S·Nathalie Matter
Jul 3, 2003·Médecine sciences : M/S·Véronique Orian-Rousseau
Dec 18, 2002·Critical Reviews in Clinical Laboratory Sciences·David NaorYoram Faitelson
Dec 26, 2015·International Journal of Molecular Sciences·Mehmet YabasGerard F Hoyne
Nov 8, 2008·Expert Opinion on Biological Therapy·Raphael Gorodetsky
Nov 21, 1998·Cell Adhesion and Communication·P HerrlichH Ponta
Apr 21, 2010·The Journal of Urology·Tobias KlatteAllan J Pantuck
May 18, 2007·The International Journal of Biochemistry & Cell Biology·Matias BlausteinAnabella Srebrow
Jun 24, 2004·Experimental Cell Research·Dirk-Steffen SchmidtMargot Zöller
Apr 9, 2008·Annals of Neurology·Kristen N SegoviaStephen A Back
Dec 17, 2008·International Journal of Cancer. Journal International Du Cancer·Peter ChuRobert J Peach
Jul 6, 2010·European Journal of Clinical Investigation·Pieter T BotImo E Hoefer

❮ Previous
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