PMID: 18414024Apr 17, 2008Paper

A spoke in the wheel: calcium spikes disrupt yeast cell cycle

Cell Cycle
Yong-Qiang Zhang, Rajini Rao

Abstract

A prerequisite of calcium signaling is the maintenance of cytoplasmic free Ca(2+) within a narrow, sub-micromolar range, compatible with cell viability. A variety of stress inducing agents and drugs can lead to a disruption of calcium homeostasis with ensuing toxicity. Amiodarone, an anti-arrhythmic drug with broad range microbicidal effect, has been shown to trigger a calcium burst in the yeast Saccharomyces cerevisiae. Recently, we reported that amiodarone elicits a starvation response, blocks cell cycle progression at multiple stages and represses the transcription of cell cycle genes. Here, we examine the connections between Ca(2+)-calcineurin signaling, nutrient sensing and regulation of the cell cycle.

Citations

Dec 8, 2010·Molecular Genetics and Genomics : MGG·Manuel J Villa-GarcíaSusan A Henry
Jan 28, 2009·Cellular Microbiology·Lukasz KozubowskiJoseph Heitman
Aug 16, 2012·The Journal of Pharmacology and Experimental Therapeutics·Elzbieta HejchmanWilliam E Courchesne
May 1, 2021·Journal of Fungi·Dominique Sanglard

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